针对猫免疫缺陷病毒同源和异源毒株的实验性疫苗保护作用。
Experimental vaccine protection against homologous and heterologous strains of feline immunodeficiency virus.
作者信息
Yamamoto J K, Hohdatsu T, Olmsted R A, Pu R, Louie H, Zochlinski H A, Acevedo V, Johnson H M, Soulds G A, Gardner M B
机构信息
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
出版信息
J Virol. 1993 Jan;67(1):601-5. doi: 10.1128/JVI.67.1.601-605.1993.
Abstract
More than 90% of cats immunized with inactivated whole infected-cell or cell-free feline immunodeficiency virus (FIV) vaccines were protected against intraperitoneal infection with 10 50% animal infectious doses of either homologous FIV Petaluma (28 of 30 cats) or heterologous FIV Dixon strain (27 of 28 cats). All 15 control cats were readily infected with either strain of FIV. Protection appears to correlate with antiviral envelope antibody levels by a mechanism yet to be determined.
摘要
用灭活的全感染细胞或无细胞猫免疫缺陷病毒（FIV）疫苗免疫的猫中，超过90%的猫在腹腔内接种10个50%动物感染剂量的同源FIV Petaluma株（30只猫中有28只）或异源FIV Dixon株（28只猫中有27只）时受到保护。所有15只对照猫都很容易被任何一种FIV毒株感染。保护作用似乎与抗病毒包膜抗体水平相关，但其机制尚待确定。
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