小肠结肠炎耶尔森菌产肠毒素的评估以及从临床材料中分离出的一株非侵袭性小肠结肠炎耶尔森菌产生的一种新型热稳定肠毒素的鉴定。
Assessment of enterotoxin production by Yersinia enterocolitica and identification of a novel heat-stable enterotoxin produced by a noninvasive Y. enterocolitica strain isolated from clinical material.
作者信息
Robins-Browne R M, Takeda T, Fasano A, Bordun A M, Dohi S, Kasuga H, Fang G, Prado V, Guerrant R L
机构信息
Department of Microbiology and Infectious Diseases, Royal Children's Hospital, Parkville, Victoria, Australia.
出版信息
Infect Immun. 1993 Feb;61(2):764-7. doi: 10.1128/iai.61.2.764-767.1993.
Abstract
Twenty-eight clinical isolates of Yersinia enterocolitica were investigated for their abilities to produce heat-stable enterotoxin (YST). All 21 invasive strains (serogroup O3 biotype 4) carried the previously described gene for YST (yst), with toxin detectable in culture supernatants from 20 strains. One of seven noninvasive, biotype 1A strains also had enterotoxic activity, despite failure to hybridize with a probe for yst. The toxin produced by this noninvasive (serogroup O6) strain resembled YST in terms of molecular size, heat stability, and solubility in methanol. It differed from YST, however, with respect to regulation of its production by temperature and its mechanism of action, which did not appear to involve cyclic GMP.
摘要
对28株小肠结肠炎耶尔森菌临床分离株产生热稳定肠毒素（YST）的能力进行了研究。所有21株侵袭性菌株（O3血清群生物型4）均携带先前描述的YST基因（yst），20株菌株的培养上清液中可检测到毒素。7株非侵袭性生物型1A菌株中的1株也具有肠毒素活性，尽管未能与yst探针杂交。该非侵袭性（O6血清群）菌株产生的毒素在分子大小、热稳定性和在甲醇中的溶解性方面与YST相似。然而，它在温度对其产生的调节及其作用机制方面与YST不同，其作用机制似乎不涉及环鸟苷酸。
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本文引用的文献
1
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Infect Immun. 1981 May;32(2):571-4. doi: 10.1128/iai.32.2.571-574.1981.
2
Partial purification and characterization of heat-stable enterotoxin produced by Yersinia enterocolitica.小肠结肠炎耶尔森氏菌产生的热稳定肠毒素的部分纯化及特性分析
Infect Immun. 1981 Feb;31(2):554-9. doi: 10.1128/iai.31.2.554-559.1981.
3
Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man.一株对人类致病的大肠杆菌产生的热稳定肠毒素的纯化与特性分析
J Biol Chem. 1980 May 25;255(10):4716-21.
4
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J Immunol Methods. 1984 Dec 31;75(2):295-307. doi: 10.1016/0022-1759(84)90113-3.
5
Characterization of the gene encoding heat-stable toxin II and preliminary molecular epidemiological studies of enterotoxigenic Escherichia coli heat-stable toxin II producers.产肠毒素大肠杆菌热稳定毒素II基因的特性分析及初步分子流行病学研究
Infect Immun. 1983 Oct;42(1):264-8. doi: 10.1128/iai.42.1.264-268.1983.
6
7
Isolation, primary structure and synthesis of heat-stable enterotoxin produced by Yersinia enterocolitica.小肠结肠炎耶尔森菌产生的热稳定肠毒素的分离、一级结构及合成
Eur J Biochem. 1985 Oct 1;152(1):199-206. doi: 10.1111/j.1432-1033.1985.tb09183.x.
8
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J Med Microbiol. 1985 Jun;19(3):297-308. doi: 10.1099/00222615-19-3-297.
9
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Rev Infect Dis. 1987 Jan-Feb;9(1):64-87. doi: 10.1093/clinids/9.1.64.
10
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J Infect Dis. 1988 Jul;158(1):224-8. doi: 10.1093/infdis/158.1.224.
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