Ruddell W S, Blendis L M, Walters C L
Gut. 1977 Jan;18(1):73-7. doi: 10.1136/gut.18.1.73.
The concentrations of nitrite and thiocyanate in fasting and pentagastrin stimulated gastric juice and in saliva have been examined. Nitrite was found in all of 17 samples of fasting gastric juice, mean 4-9 +/- 1-1 muM. Stimulation of gastric secretion with pentagastrin caused no significant change in nitrite concentration. Thiocyanate was detected in all of 21 samples of fasting gastric juice and the difference in concentration between smokers and non-smokers probably reflects similar differences in saliva. In contrast to the nitrite data there was a significant drop in thiocyanate concentration of gastric juice after pentagastrin from 0-9 +/- 0-1 mM to 0-3 +/- 0-04 mM, suggesting a salivary origin for the thiocyanate in gastric juice. Thiocyanate is a powerful catalyst of nitrosation, which, together with small amounts of nitrite and naturally occurring amines could lead to the intragastric formation of carcinogenic nitrosamines and in certain circumstances be a factor in the aetiology of gastric cancer.
对空腹及经五肽胃泌素刺激后的胃液和唾液中的亚硝酸盐及硫氰酸盐浓度进行了检测。在17份空腹胃液样本中均检测到亚硝酸盐，平均浓度为4.9±1.1μM。用五肽胃泌素刺激胃液分泌后，亚硝酸盐浓度无显著变化。在21份空腹胃液样本中均检测到硫氰酸盐，吸烟者与非吸烟者之间硫氰酸盐浓度的差异可能反映了唾液中类似的差异。与亚硝酸盐数据不同，经五肽胃泌素刺激后，胃液中硫氰酸盐浓度从0.9±0.1mM显著降至0.3±0.04mM，提示胃液中的硫氰酸盐来源于唾液。硫氰酸盐是亚硝化作用的强效催化剂，它与少量亚硝酸盐及天然存在的胺类物质一起，可能导致胃内致癌亚硝胺的形成，在某些情况下是胃癌病因学中的一个因素。
