人体胃内一氧化氮的产生：呼出气体中的测量
Intragastric nitric oxide production in humans: measurements in expelled air.
作者信息
Lundberg J O, Weitzberg E, Lundberg J M, Alving K
机构信息
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
出版信息
Gut. 1994 Nov;35(11):1543-6. doi: 10.1136/gut.35.11.1543.
Abstract
High values (800-6000 parts per billion) of nitric oxide (NO) in expelled air from the stomach were shown in humans by chemiluminescence technique. These NO values were more than 100 times higher than those found in orally exhaled air. Intragastric NO production is probably non-enzymatic, requiring an acidic environment, as NO in expelled air was reduced by 95% after pretreatment with the proton pump inhibitor omeprazole. Furthermore, large amounts of NO were formed in vitro from lettuce and saliva when placed in hydrogen chloride (pH < 2). In conclusion, large amounts of NO are formed intragastrically in humans and this source of NO may be of importance for the integrity of the gastric mucosa in health and disease. Measurements of NO in expelled air might be of value as a non-invasive method for estimation of gastric acidity.
摘要
通过化学发光技术显示，人类呼出的胃内气体中一氧化氮（NO）含量很高（800 - 6000 ppb）。这些NO值比口腔呼出气体中的NO值高出100多倍。胃内NO的产生可能是非酶促的，需要酸性环境，因为在用质子泵抑制剂奥美拉唑预处理后，呼出气体中的NO减少了95%。此外，当生菜和唾液置于氯化氢（pH < 2）中时，体外会形成大量NO。总之，人类胃内会形成大量NO，这种NO来源可能对健康和疾病状态下胃黏膜的完整性具有重要意义。测量呼出气体中的NO可能作为一种估计胃酸度的非侵入性方法具有价值。
相似文献
1
Intragastric nitric oxide production in humans: measurements in expelled air.人体胃内一氧化氮的产生：呼出气体中的测量
Gut. 1994 Nov;35(11):1543-6. doi: 10.1136/gut.35.11.1543.
2
Intragastric nitric oxide/nitrite in Helicobacter pylori-infected subjects.
Scand J Gastroenterol. 2001 Apr;36(4):347-50. doi: 10.1080/003655201300051054.
3
A placebo-controlled trial to assess the effects of 8 days of dosing with rabeprazole versus omeprazole on 24-h intragastric acidity and plasma gastrin concentrations in young healthy male subjects.一项安慰剂对照试验，旨在评估雷贝拉唑与奥美拉唑连续8天给药对年轻健康男性受试者24小时胃内酸度和血浆胃泌素浓度的影响。
Aliment Pharmacol Ther. 1998 Nov;12(11):1079-89. doi: 10.1046/j.1365-2036.1998.00418.x.
4
Proanthocyanidins in buckwheat flour can reduce salivary nitrite to nitric oxide in the stomach.荞麦粉中的原花青素可将胃中的唾液亚硝酸盐还原为一氧化氮。
Plant Foods Hum Nutr. 2010 Mar;65(1):1-7. doi: 10.1007/s11130-009-0144-x.
5
Intragastric nitric oxide is abolished in intubated patients and restored by nitrite.气管插管患者胃内一氧化氮消失，而亚硝酸盐可使其恢复。
Crit Care Med. 2005 Aug;33(8):1722-7. doi: 10.1097/01.ccm.0000171204.59502.aa.
6
Effects of pumaprazole (BY841), a novel reversible proton pump antagonist, and of omeprazole, on intragastric acidity before and after cure of Helicobacter pylori infection.新型可逆质子泵拮抗剂普马拉唑（BY841）和奥美拉唑对幽门螺杆菌感染治愈前后胃内酸度的影响。
Aliment Pharmacol Ther. 1999 Jan;13(1):27-34. doi: 10.1046/j.1365-2036.1999.00440.x.
7
Comparison of the effect of a single dose of omeprazole or lansoprazole on intragastric pH in Japanese participants: a two-way crossover study.奥美拉唑或兰索拉唑单次给药对日本受试者胃内 pH 的影响比较：一项双交叉研究。
J Chin Med Assoc. 2013 Mar;76(3):131-4. doi: 10.1016/j.jcma.2012.11.006. Epub 2013 Jan 24.
8
Salivary contribution to exhaled nitric oxide.唾液对呼出一氧化氮的影响。
Eur Respir J. 1999 Feb;13(2):327-33. doi: 10.1034/j.1399-3003.1999.13b18.x.
9
Bedtime ranitidine does not eliminate the need for a second daily dose of omeprazole to suppress nocturnal gastric pH.睡前服用雷尼替丁并不能消除每日额外服用一剂奥美拉唑以抑制夜间胃内pH值的必要性。
Aliment Pharmacol Ther. 1999 May;13(5):675-8. doi: 10.1046/j.1365-2036.1999.00499.x.
10
Exhaled nitric oxide levels in exacerbations of asthma, chronic obstructive pulmonary disease and pneumonia.哮喘、慢性阻塞性肺疾病和肺炎急性加重期的呼出气一氧化氮水平。
Saudi Med J. 2001 Mar;22(3):249-53.
引用本文的文献
1
Interplay between dietary nitrate metabolism and proton pump inhibitors: impact on nitric oxide pathways and health outcomes.膳食硝酸盐代谢与质子泵抑制剂之间的相互作用：对一氧化氮途径和健康结果的影响。
Front Nutr. 2025 Sep 2;12:1648219. doi: 10.3389/fnut.2025.1648219. eCollection 2025.
2
Nitrates and Nitrites in Vegetables and the Health Risk.蔬菜中的硝酸盐和亚硝酸盐与健康风险
Foods. 2025 Aug 29;14(17):3037. doi: 10.3390/foods14173037.
3
Gut microbiome and gastric cancer: microbial interactions and therapeutic potential.肠道微生物群与胃癌：微生物相互作用及治疗潜力
Gut Pathog. 2025 Jul 26;17(1):56. doi: 10.1186/s13099-025-00729-w.
4
A critical role for gastric xanthine oxidoreductase in the formation of S-nitrosothiols and blood pressure responses to nitrite in rats.胃黄嘌呤氧化还原酶在大鼠体内S-亚硝基硫醇形成及对亚硝酸盐的血压反应中起关键作用。
Redox Biol. 2025 Jun 30;85:103748. doi: 10.1016/j.redox.2025.103748.
5
Effects of Beetroot Juice on Physical Performance in Professional Athletes and Healthy Individuals: An Umbrella Review.甜菜根汁对职业运动员和健康个体体能表现的影响：一项系统性综述。
Nutrients. 2025 Jun 9;17(12):1958. doi: 10.3390/nu17121958.
6
Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms.诱导型一氧化氮合酶（iNOS）：仅仅是一种诱导酶吗？对一氧化氮合酶同工型分类的重新思考。
Pharmacol Res. 2025 Jun;216:107781. doi: 10.1016/j.phrs.2025.107781. Epub 2025 May 17.
7
Nitrate as Warden of Nitric Oxide Homeostasis in Mammals.硝酸盐作为哺乳动物一氧化氮稳态的守护者。
Nutrients. 2025 Apr 30;17(9):1544. doi: 10.3390/nu17091544.
8
Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide.二甲双胍对2型糖尿病肝脏糖异生的抑制作用：一氧化氮的互补作用
Med Gas Res. 2025 Dec 1;15(4):507-519. doi: 10.4103/mgr.MEDGASRES-D-24-00100. Epub 2025 Apr 29.
9
Promotion of nitric oxide production: mechanisms, strategies, and possibilities.一氧化氮生成的促进：机制、策略及可能性
Front Physiol. 2025 Jan 23;16:1545044. doi: 10.3389/fphys.2025.1545044. eCollection 2025.
10
Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease.基于药物遗传学对黄嘌呤脱氢酶在心血管疾病中进行治疗性开发的潜在机会。
Antioxidants (Basel). 2024 Nov 22;13(12):1439. doi: 10.3390/antiox13121439.
本文引用的文献
1
A study of the changes in pH of gastric contents in peptic ulcer using the twenty-four hour test meal.一项使用24小时试餐对消化性溃疡患者胃内容物pH值变化的研究。
Gastroenterology. 1951 Jul;18(3):377-90.
2
Effect of once daily intravenous and oral omeprazole on 24-hour intragastric acidity in healthy subjects.每日一次静脉注射及口服奥美拉唑对健康受试者24小时胃内酸度的影响。
Scand J Gastroenterol. 1993 Feb;28(2):179-84. doi: 10.3109/00365529309096067.
3
Measurement of nitric oxide in biological models.生物模型中一氧化氮的测量。
FASEB J. 1993 Feb 1;7(2):349-60. doi: 10.1096/fasebj.7.2.8440411.
4
Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance.第十三届加德姆纪念讲座。胃微循环调节中的神经元和内皮衍生介质：平衡中的完整性。
Br J Pharmacol. 1993 Sep;110(1):3-17. doi: 10.1111/j.1476-5381.1993.tb13763.x.
5
The role of the L-arginine/nitric oxide pathway for relaxation of the human lower oesophageal sphincter.L-精氨酸/一氧化氮途径在人下食管括约肌舒张中的作用。
Acta Physiol Scand. 1993 Dec;149(4):451-9. doi: 10.1111/j.1748-1716.1993.tb09642.x.
6
Nitric oxide inhibition intensifies cold-restraint induced gastric ulcers in rats.一氧化氮抑制会加剧大鼠冷束缚诱导的胃溃疡。
Experientia. 1993 Apr 15;49(4):304-7. doi: 10.1007/BF01923407.
7
Increased amount of nitric oxide in exhaled air of asthmatics.哮喘患者呼出气体中一氧化氮含量增加。
Eur Respir J. 1993 Oct;6(9):1368-70.
8
Nitrates, nitrites and gastric cancer in Great Britain.英国的硝酸盐、亚硝酸盐与胃癌
Nature. 1985;313(6004):620-5. doi: 10.1038/313620a0.
9
Gastroesophageal reflux in patients with asthma and chronic bronchitis.哮喘和慢性支气管炎患者的胃食管反流
Am Rev Respir Dis. 1987 Feb;135(2):327-32. doi: 10.1164/arrd.1987.135.2.327.
10
The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load.
Food Chem Toxicol. 1988 Feb;26(2):93-7. doi: 10.1016/0278-6915(88)90104-4.
Zotero 插件