Stewart J P, Arrand J R
Department of Molecular Biology, Paterson Institute for Cancer Research, Christie CRC Cancer Centre, Manchester, UK.
Hum Pathol. 1993 Mar;24(3):239-42. doi: 10.1016/0046-8177(93)90032-c.
It has been known for some time that the Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The tumor cells are known to harbor EBV in a latent state. Latently-infected B cells that have become growth transformed by EBV in vitro express some 10 antigens, two of which (Epstein-Barr nuclear antigen 2 [EBNA2] and the latent membrane protein [LMP]) are associated with cellular transformation. We evaluated the expression of these two EBV antigens in NPC by probing tissue sections with monoclonal antibodies. We found that EBNA2 was not expressed and that LMP was expressed in seven of nine biopsy specimens. It is therefore postulated that either there are subsets of NPC or that LMP may be involved only in certain stages of tumor formation.
一段时间以来，人们已经知道爱泼斯坦-巴尔病毒（EBV）与鼻咽癌（NPC）有关。已知肿瘤细胞潜伏感染EBV。在体外已被EBV转化为生长转化型的潜伏感染B细胞表达约10种抗原，其中两种（爱泼斯坦-巴尔核抗原2 [EBNA2] 和潜伏膜蛋白 [LMP]）与细胞转化有关。我们通过用单克隆抗体探测组织切片来评估这两种EBV抗原在NPC中的表达。我们发现9份活检标本中有7份未表达EBNA2但表达LMP。因此推测，要么存在NPC的不同亚群，要么LMP可能仅参与肿瘤形成的某些阶段。
