Ville Y, Fernandez H, Samuel D, Bismuth H, Frydman R
Service de Gynécologie-Obstétrique, Hôpital A. Béclère, Clamart, France.
Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):896-902. doi: 10.1016/s0002-9378(12)90841-8.
Our aim was to evaluate the course and outcome of pregnancy in orthotopic liver transplant recipients.
We report the course and outcome of 19 pregnancies in 19 orthotopic recipients since 1985, out of 775 patients who have undergone liver transplant in our center. Statistical analysis was based on the chi 2 test with a 95% confidence interval, when appropriate.
There were four spontaneous abortions and three therapeutic abortions for impaired liver function. One current pregnancy is uncomplicated at 19 weeks' gestation. Eleven women have given birth to 11 healthy infants at 38 +/- 1.5 weeks' gestation. There were no preterm deliveries. Birth weight was normal for gestational age in 10 of the 11 cases, with a mean value of 2990 +/- 370 gm. The main complications in the 11 successful pregnancies were hypertension in three and graft dysfunction at 37 weeks' gestation in another.
Pregnancy is successful in a large proportion of liver transplant recipients, but it must be planned and managed as a high-risk situation by both an obstetrician and a surgeon.
我们的目的是评估原位肝移植受者的妊娠过程及结局。
我们报告了自1985年以来，在我们中心接受肝移植的775例患者中，19例原位肝移植受者的19次妊娠过程及结局。在适当的时候，采用卡方检验及95%置信区间进行统计学分析。
有4例自然流产，3例因肝功能受损而行治疗性流产。1例目前妊娠19周，情况正常。11名女性在妊娠38±1.5周时产下11名健康婴儿。无早产情况。11例中有10例出生体重与孕周相符，平均值为2990±370克。11例成功妊娠的主要并发症为3例高血压，另1例在妊娠37周时出现移植物功能障碍。
大部分肝移植受者妊娠成功，但产科医生和外科医生必须将其作为高危情况进行规划和管理。
