针对人巨细胞病毒DNA聚合酶的体液免疫反应。
Humoral immune response to human cytomegalovirus DNA polymerase.
作者信息
Landini M P, Lazzarotto T, Ertl P F
机构信息
Institute of Microbiology, University of Bologna, St. Orsola General Hospital, Italy.
出版信息
J Clin Microbiol. 1993 Mar;31(3):724-6. doi: 10.1128/jcm.31.3.724-726.1993.
Abstract
In this work, we show that antibodies to baculovirus recombinant DNA polymerase of human cytomegalovirus are present in human sera during natural infection. Specific antibody was found to be of the immunoglobulin G class, produced at low titers only for a short period of time at the beginning of acute infection and not detectable in sera from patients with a convalescent or a latent phase of infection. These results were compared with those obtained with procaryotically expressed p52, the polymerase accessory protein.
摘要
在本研究中，我们表明，在自然感染期间，人血清中存在针对人巨细胞病毒杆状病毒重组DNA聚合酶的抗体。发现特异性抗体属于免疫球蛋白G类，仅在急性感染开始时短时间内以低滴度产生，在处于恢复期或感染潜伏期的患者血清中无法检测到。将这些结果与用原核表达的聚合酶辅助蛋白p52获得的结果进行了比较。
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本文引用的文献
1
Human immune response to cytomegalovirus structural polypeptides studied by immunoblotting.
J Med Virol. 1985 Dec;17(4):303-11. doi: 10.1002/jmv.1890170403.
2
Antibodies to human cytomegalovirus structural polypeptides during primary infection.原发性感染期间针对人巨细胞病毒结构多肽的抗体
J Virol Methods. 1988 Dec;22(2-3):309-17. doi: 10.1016/0166-0934(88)90113-9.
3
Immunoaffinity purification of a 72K early antigen of human cytomegalovirus: analysis of humoral and cell-mediated immunity to the purified polypeptide.人巨细胞病毒72K早期抗原的免疫亲和纯化：对纯化多肽的体液免疫和细胞介导免疫分析
J Gen Virol. 1987 Sep;68 ( Pt 9):2371-8. doi: 10.1099/0022-1317-68-9-2371.
4
Antibody response to recombinant lambda gt11 fusion proteins in cytomegalovirus infection.巨细胞病毒感染中对重组λgt11融合蛋白的抗体反应。
J Clin Microbiol. 1989 Oct;27(10):2324-7. doi: 10.1128/jcm.27.10.2324-2327.1989.
5
Identification and preliminary use of recombinant lambda gt11 fusion proteins in human cytomegalovirus diagnosis.
J Gen Virol. 1989 May;70 ( Pt 5):1247-51. doi: 10.1099/0022-1317-70-5-1247.
6
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Rev Infect Dis. 1990 Sep-Oct;12 Suppl 7:S839-48. doi: 10.1093/clinids/12.supplement_7.s839.
7
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