Umeki S
Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Chest. 1993 Oct;104(4):1191-3. doi: 10.1378/chest.104.4.1191.
The effects of erythromycin on the NADPH oxidase activity in the neutrophils of normal subjects and patients with bronchiolitis were investigated. In the patients receiving erythromycin, NADPH oxidase activity was significantly lower in a whole-cell system than that before therapy. Erythromycin was also found to inhibit the superoxide generation of neutrophils exposed to phorbol myristate acetate in a whole-cell system and the activation of superoxide-generating NADPH oxidase by sodium lauryl sulfate (sodium dodecyl sulfate) in a cell-free system. The concentration of the drug required for 50 percent inhibition of the oxidase was 0.7 mM in the whole-cell system and 0.2 mM in the cell-free system. These results suggest that erythromycin, an antibiotic which penetrates well into human neutrophils, may exhibit an anti-inflammatory action due to inhibiting of neutrophil NADPH oxidase activation.
研究了红霉素对正常受试者和细支气管炎患者中性粒细胞中NADPH氧化酶活性的影响。在接受红霉素治疗的患者中，全细胞系统中的NADPH氧化酶活性明显低于治疗前。还发现红霉素可抑制全细胞系统中暴露于佛波酯肉豆蔻酸酯的中性粒细胞产生超氧化物，以及在无细胞系统中抑制月桂基硫酸钠（十二烷基硫酸钠）对产生超氧化物的NADPH氧化酶的激活。在全细胞系统中，抑制氧化酶50%所需的药物浓度为0.7 mM，在无细胞系统中为0.2 mM。这些结果表明，红霉素这种能很好地渗透到人类中性粒细胞中的抗生素，可能由于抑制中性粒细胞NADPH氧化酶的激活而表现出抗炎作用。
