Koike K
First Department of Internal Medicine, Tokyo University.
Nihon Rinsho. 1993 Feb;51(2):536-41.
The exact role of hepatitis B virus (HBV) in hepatocarcinogenesis is not known. We generated HBV x gene transgenic mice under the hypothesis that the viral transactivator may alter the host gene expression and lead to the development of hepatocellular carcinoma. The x gene under its own regulatory element caused progressive histopathological changes specifically in the transgenic mouse liver, beginning with multifocal foci of altered hepatocytes, followed by the appearance of neoplasia. This finding shows, for the first time, the direct involvement of HBV in the development of liver cancer. Analyses of events that follow the expression of the x gene suggest that the x gene acts at the early stage of carcinogenesis in the liver.
乙型肝炎病毒（HBV）在肝癌发生过程中的确切作用尚不清楚。我们在病毒反式激活因子可能改变宿主基因表达并导致肝细胞癌发生的假设下，培育出了乙肝病毒X基因转基因小鼠。在其自身调控元件作用下的X基因在转基因小鼠肝脏中引发了渐进性组织病理学变化，起始于多灶性肝细胞改变灶，随后出现肿瘤形成。这一发现首次表明HBV直接参与了肝癌的发生。对X基因表达后一系列事件的分析表明，X基因在肝癌发生的早期阶段发挥作用。
