由单纯疱疹病毒引起的实验性前庭神经炎。

Experimental vestibular neuritis induced by herpes simplex virus.

作者信息

Hirata Y, Sugita T, Gyo K, Yanagihara N

机构信息

Department of Otolaryngology, Ehime University School of Medicine, Japan.

出版信息

Acta Otolaryngol Suppl. 1993;503:79-81. doi: 10.3109/00016489309128079.

DOI:10.3109/00016489309128079

PMID:8385869

Abstract

An animal model of vestibular neuritis was developed by inoculating herpes simplex virus type 1 (HSV-1) in the auricle of a mouse. Deviation of the body was observed in 4 of 30 mice 6 days after inoculation. These animals were sacrificed 6 to 10 days after inoculation and the vestibular nerve was examined histopathologically and immunohistochemically. The HSV-1 antigens were recognized exclusively in Scarpa's ganglion of the vestibular nerve in 2 of 4 mice in which signs of vestibular involvement were manifested.

摘要

通过将1型单纯疱疹病毒（HSV-1）接种到小鼠耳廓来建立前庭神经炎的动物模型。接种6天后，在30只小鼠中有4只出现身体偏斜。这些动物在接种后6至10天被处死，并对前庭神经进行组织病理学和免疫组织化学检查。在出现前庭受累迹象的4只小鼠中的2只中，仅在前庭神经的斯卡帕神经节中识别出HSV-1抗原。