Chase C C, Lohff C, Letchworth G J
Department of Veterinary Science, University of Wisconsin-Madison 53706.
Virology. 1993 May;194(1):365-9. doi: 10.1006/viro.1993.1269.
Bovine cell lines individually expressing two related herpesviral proteins, pseudorabies virus glycoprotein 50 and herpes simplex virus type 1 glycoprotein D, were examined for their susceptibility/resistance to infection with several alphaherpesviruses. Cell lines expressing gp50 or gD-1 resisted plaque formation by the homologous virus more than by the heterologous viruses. Bovine cells expressing bovine herpesvirus 1 glycoprotein IV (gIV) were susceptible to infection with three other bovine herpesviruses: bovine herpesvirus 2, bovine herpesvirus 4 (BHV-4) and alcelaphine herpesvirus 1. One line of gIV-expressing cells was resistant to the formation of BHV-4 plaques, suggesting that a cell-associated factor may be responsible for inhibiting cell-to-cell spread.
对单独表达两种相关疱疹病毒蛋白（伪狂犬病病毒糖蛋白50和单纯疱疹病毒1型糖蛋白D）的牛细胞系，检测了它们对几种α疱疹病毒感染的易感性/抗性。表达gp50或gD-1的细胞系对同源病毒形成蚀斑的抵抗能力强于对异源病毒。表达牛疱疹病毒1型糖蛋白IV（gIV）的牛细胞对其他三种牛疱疹病毒易感：牛疱疹病毒2、牛疱疹病毒4（BHV-4）和非洲猪瘟病毒1型。一个表达gIV的细胞系对BHV-4蚀斑的形成具有抗性，这表明一种细胞相关因子可能负责抑制细胞间传播。
