Yanagihara D, Watanabe S, Mitarai G
Laboratory of Exercise Physiology, Faculty of Physical Education, Chukyo University, Toyota, Japan.
Neurosci Res. 1993 Jan;16(1):25-32. doi: 10.1016/0168-0102(93)90005-b.
The afferent connections of the lateral lobe of the valvula cerebelli in goldfish were investigated by retrograde labeling with horseradish peroxidase (HRP). Retrogradely labeled neurons were observed ipsilaterally in the lateral nucleus of the valvula and contralaterally in the inferior olivary nucleus after HRP injection into all parts of the lateral valvula. The valvulopetal projections from these nuclei were topographically arranged. After HRP injection confined to the rostral half of the lateral valvula, labeled neurons were also found ipsilaterally in the octavolateral and trigeminal cell groups: the eminentia granularis, the medial nucleus of the octavolateralis column, and the isthmic primary sensory trigeminal nucleus. HRP injection confined to the caudal half of the lateral valvula resulted in retrograde labeling of the following vision-related cell groups; the central pretectal nucleus, nucleus paracommissuralis, and the nucleus isthmi. However, the octavolateral and trigeminal cell groups did not project to the caudal half of the lateral valvula. These data provide insight into central nervous integration of visual and vestibular information, and help reveal the mechanism of the dorsal light response (DLR). Bilateral lesions of either the valvula cerebelli or pretectal area completely abolish this visually-guided response, but lesions of the optic tectum have no such effect. The pretectal nuclei (central pretectal nucleus, nucleus paracommissuralis) project to the lateral valvula directly, not via the optic tectum. These direct projections from the pretectal accessory optic nuclei to the lateral valvula may control the DLR. On the other hand, the lateral valvula receives vestibular and lateral line inputs indirectly, via the eminentia granularis and the medial nucleus of the octavolateralis column, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
采用辣根过氧化物酶（HRP）逆行标记法，研究了金鱼小脑瓣叶外侧叶的传入联系。将HRP注入外侧瓣叶的各个部位后，在瓣叶外侧核同侧及下橄榄核对侧观察到逆行标记的神经元。来自这些核的向瓣叶投射呈拓扑排列。将HRP注入外侧瓣叶的 Rostral 半部后，在同侧的八分体外侧和三叉神经细胞群中也发现了标记神经元，即颗粒隆起、八分体外侧柱内侧核和峡部初级感觉三叉神经核。将HRP注入外侧瓣叶的尾半部导致以下与视觉相关的细胞群逆行标记：中央顶盖前核、连合旁核和峡部核。然而，八分体外侧和三叉神经细胞群不投射到外侧瓣叶的尾半部。这些数据为视觉和前庭信息的中枢神经整合提供了见解，并有助于揭示背光反应（DLR）的机制。小脑瓣叶或顶盖前区的双侧损伤完全消除了这种视觉引导反应，但视顶盖损伤没有这种效果。顶盖前核（中央顶盖前核、连合旁核）直接投射到外侧瓣叶，不通过视顶盖。从顶盖前附属视核到外侧瓣叶的这些直接投射可能控制DLR。另一方面，外侧瓣叶分别通过颗粒隆起和八分体外侧柱内侧核间接接受前庭和侧线输入。（摘要截短于250字）
