• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

低放养密度感染试验中鲤疱疹病毒3型（CyHV-3）疾病周期及影响CyHV-3传播因素的研究

Investigation of Cyprinid Herpesvirus 3 (CyHV-3) Disease Periods and Factors Influencing CyHV-3 Transmission in A Low Stocking Density Infection Trial.

作者信息

Tolo Isaiah E, Bajer Przemyslaw G, Wolf Tiffany M, Mor Sunil K, Phelps Nicholas B D

机构信息

Minnesota Aquatic Invasive Species Research Center, University of Minnesota, St. Paul, MN 55108, USA.

Department of Fisheries, Wildlife, and Conservation Biology, College of Food, Agriculture and Natural Resource Sciences, University of Minnesota, St. Paul, MN 55108, USA.

出版信息

Animals (Basel). 2021 Dec 21;12(1):2. doi: 10.3390/ani12010002.

DOI:10.3390/ani12010002
PMID:35011108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8749781/
Abstract

Cyprinid herpesvirus 3 (CyHV-3) is the etiological agent of koi herpesvirus disease (KHVD) and important pathogen of aquaculture and wild populations of common carp worldwide. Understanding the relative contributions of direct and indirect transmission of CyHV-3 as well as the factors that drive CyHV-3 transmission can clarify the importance of environmental disease vectors and is valuable for informing disease modeling efforts. To study the mechanisms and factors driving CyHV-3 transmission we conducted infection trials that determined the kinetics of KHVD and the contributions of direct and indirect forms of CyHV-3 transmission, as well as the contributions of contact rate, viral load, pathogenicity and contact type. The incubation period of KHVD was 5.88 + 1.75 days and the symptomatic period was 5.31 + 0.87 days. Direct transmission was determined to be the primary mechanism of CyHV-3 transmission (OR = 25.08, 95%CI = 10.73-99.99, = 4.29 × 10) and transmission primarily occurred during the incubation period of KHVD. Direct transmission decreased in the symptomatic period of disease. Transmissibility of CyHV-3 and indirect transmission increased during the symptomatic period of disease, correlating with increased viral loads. Additionally, potential virulence-transmission tradeoffs and disease avoidance behaviors relevant to CyHV-3 transmission were identified.

摘要

鲤疱疹病毒3型（CyHV-3）是锦鲤疱疹病毒病（KHVD）的病原体，也是全球范围内鲤鱼养殖和野生种群的重要病原体。了解CyHV-3直接传播和间接传播的相对作用以及驱动CyHV-3传播的因素，能够阐明环境疾病载体的重要性，对疾病建模工作具有重要价值。为了研究驱动CyHV-3传播的机制和因素，我们进行了感染试验，确定了KHVD的发病过程以及CyHV-3直接传播和间接传播的作用，以及接触率、病毒载量、致病性和接触类型的作用。KHVD的潜伏期为5.88±1.75天，症状期为5.31±0.87天。直接传播被确定为CyHV-3传播的主要机制（比值比=25.08，95%置信区间=10.73-99.99，P=4.29×10），且传播主要发生在KHVD的潜伏期。在疾病的症状期，直接传播减少。在疾病的症状期，CyHV-3的传播性和间接传播增加，这与病毒载量增加相关。此外，还确定了与CyHV-3传播相关的潜在毒力-传播权衡和疾病规避行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/9049bfbf3396/animals-12-00002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/4507be7cfc8a/animals-12-00002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/78c043baf6a2/animals-12-00002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/4c5354c349f7/animals-12-00002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/f703089475c1/animals-12-00002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/e78e5fe1bd39/animals-12-00002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/e7ce906e8c0e/animals-12-00002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/9049bfbf3396/animals-12-00002-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/4507be7cfc8a/animals-12-00002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/78c043baf6a2/animals-12-00002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/4c5354c349f7/animals-12-00002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/f703089475c1/animals-12-00002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/e78e5fe1bd39/animals-12-00002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/e7ce906e8c0e/animals-12-00002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c11/8749781/9049bfbf3396/animals-12-00002-g007.jpg

相似文献

1
Investigation of Cyprinid Herpesvirus 3 (CyHV-3) Disease Periods and Factors Influencing CyHV-3 Transmission in A Low Stocking Density Infection Trial.低放养密度感染试验中鲤疱疹病毒3型（CyHV-3）疾病周期及影响CyHV-3传播因素的研究
Animals (Basel). 2021 Dec 21;12(1):2. doi: 10.3390/ani12010002.
2
CyHV-3: the third cyprinid herpesvirus.鲤疱疹病毒3型：第三种鲤科疱疹病毒。
Dis Aquat Organ. 2013 Jul 22;105(2):163-74. doi: 10.3354/dao02614.
3
Type I interferon responses of common carp strains with different levels of resistance to koi herpesvirus disease during infection with CyHV-3 or SVCV.感染 CyHV-3 或 SVCV 时，不同鲤鱼疱疹病毒病抗性水平的鲤鱼品系的 I 型干扰素反应。
Fish Shellfish Immunol. 2019 Apr;87:809-819. doi: 10.1016/j.fsi.2019.02.022. Epub 2019 Feb 15.
4
Characteristics of cyprinid herpesvirus 3 in different phases of infection: implications for disease transmission and control.鲤鱼疱疹病毒 3 在不同感染阶段的特征：对疾病传播和控制的影响。
Virus Res. 2014 Aug 8;188:45-53. doi: 10.1016/j.virusres.2014.03.024. Epub 2014 Apr 3.
5
Targeted genomic enrichment and sequencing of CyHV-3 from carp tissues confirms low nucleotide diversity and mixed genotype infections.对鲤鱼组织中鲤疱疹病毒3型进行靶向基因组富集和测序，证实其核苷酸多样性较低且存在混合基因型感染。
PeerJ. 2016 Sep 27;4:e2516. doi: 10.7717/peerj.2516. eCollection 2016.
6
Autophagy induced by Cyprinid herpesvirus 3 (CyHV-3) facilitated intracellular viral replication and extracellular viral yields in common carp brain cells.鲤疱疹病毒3型（CyHV-3）诱导的自噬促进了鲤鱼脑细胞内的病毒复制和细胞外的病毒产量。
Fish Shellfish Immunol. 2023 Oct;141:109049. doi: 10.1016/j.fsi.2023.109049. Epub 2023 Sep 9.
7
Transmission of Cyprinid herpesvirus-3 (CyHV-3) from goldfish to naïve common carp by cohabitation.通过混养将鲤鱼疱疹病毒 3 型（CyHV-3）从金鱼传播给无经验的鲤鱼。
Res Vet Sci. 2011 Jun;90(3):536-9. doi: 10.1016/j.rvsc.2010.07.008. Epub 2010 Aug 17.
8
Emodin resists to Cyprinid herpesvirus 3 replication via the pathways of Nrf2/Keap1-ARE and NF-κB in the ornamental koi carp (Cyprinus carpio haematopterus).大黄素通过Nrf2/Keap1-ARE和NF-κB途径抵抗观赏锦鲤（Cyprinus carpio haematopterus）中鲤疱疹病毒3的复制。
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Aug;246:109023. doi: 10.1016/j.cbpc.2021.109023. Epub 2021 Feb 26.
9
Laboratory validation of a lateral flow device for the detection of CyHV-3 antigens in gill swabs.实验室验证侧向流设备用于检测鳃拭子中的 CyHV-3 抗原。
J Virol Methods. 2013 Nov;193(2):679-82. doi: 10.1016/j.jviromet.2013.07.034. Epub 2013 Jul 26.
10
Oral vaccination using Artemia coated with recombinant Saccharomyces cerevisiae expressing cyprinid herpesvirus-3 envelope antigen induces protective immunity in common carp (Cyprinus carpio var. Jian) larvae.口服接种用丰年虫包被表达鲤疱疹病毒 3 囊膜抗原的重组酿酒酵母诱导建鲤幼鱼的保护性免疫。
Res Vet Sci. 2020 Jun;130:184-192. doi: 10.1016/j.rvsc.2020.03.013. Epub 2020 Mar 7.

本文引用的文献

1
Susceptibility of Pimephales promelas and Carassius auratus to a strain of koi herpesvirus isolated from wild Cyprinus carpio in North America.虹鳟和金鱼对从北美的野生鲤鱼中分离到的锦鲤疱疹病毒的易感性。
Sci Rep. 2021 Jan 21;11(1):1985. doi: 10.1038/s41598-021-81477-0.
2
Seroconversion and Skin Mucosal Parameters during Koi Herpesvirus Shedding in Common Carp, .锦鲤疱疹病毒在鲤鱼中排毒期间的血清转化和皮肤粘膜参数。
Int J Mol Sci. 2020 Nov 11;21(22):8482. doi: 10.3390/ijms21228482.
3
Mass mortality associated with koi herpesvirus in common carp in Iraq.
伊拉克鲤鱼中与锦鲤疱疹病毒相关的大规模死亡事件。
Heliyon. 2020 Aug 31;6(8):e04827. doi: 10.1016/j.heliyon.2020.e04827. eCollection 2020 Aug.
4
Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea.韩国社区治疗中心中无症状和有症状的 SARS-CoV-2 感染患者的临床病程和分子病毒脱落情况。
JAMA Intern Med. 2020 Nov 1;180(11):1447-1452. doi: 10.1001/jamainternmed.2020.3862.
5
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.报告动物研究：ARRIVE 指南 2.0 的解释和说明。
PLoS Biol. 2020 Jul 14;18(7):e3000411. doi: 10.1371/journal.pbio.3000411. eCollection 2020 Jul.
6
Reducing risks from coronavirus transmission in the home-the role of viral load.降低家庭中冠状病毒传播的风险——病毒载量的作用
BMJ. 2020 May 6;369:m1728. doi: 10.1136/bmj.m1728.
7
Koi herpesvirus (KHV) and KHV disease (KHVD) - a recently updated overview.锦鲤疱疹病毒（KHV）和锦鲤疱疹病毒病（KHVD）——最新综述。
J Appl Microbiol. 2020 Jul;129(1):98-103. doi: 10.1111/jam.14616. Epub 2020 Mar 8.
8
The First Detection of Koi Herpesvirus (CyHV3) in Migratory Wild Ducks in North America.北美迁徙野鸭中首次检测到锦鲤疱疹病毒（CyHV3）
J Aquat Anim Health. 2020 Mar;32(1):28-31. doi: 10.1002/aah.10092. Epub 2020 Jan 21.
9
Koi herpesvirus and carp oedema virus: Infections and coinfections during mortality events of wild common carp in the United States.锦鲤疱疹病毒和鲤鱼水肿病毒：美国野生鲤鱼死亡事件中的感染和合并感染。
J Fish Dis. 2019 Nov;42(11):1609-1621. doi: 10.1111/jfd.13082.
10
The susceptibility of silver crucian carp (Carassius auratus langsdorfii) to infection with koi herpesvirus (KHV).银鲫（Carassius auratus langsdorfii）对锦鲤疱疹病毒（KHV）感染的敏感性。
J Fish Dis. 2019 Oct;42(10):1333-1340. doi: 10.1111/jfd.13054. Epub 2019 Jul 25.