Coursaget P, Krawczynski K, Buisson Y, Nizou C, Molinié C
Institut de Virologie de Tours, Faculté de Pharmacie, France.
J Med Virol. 1993 Feb;39(2):163-6. doi: 10.1002/jmv.1890390214.
Serologic markers of HCV and HEV were investigated in 74 French soldiers with non-A, non-B hepatitis and in 18 patients involved in an outbreak of non-A,non-B hepatitis in Algeria. Moreover, anti-HCV antibodies were detected in 13 patients with non-A,non-B hepatitis of parenteral origin. HEV antibodies were investigated in 61-65% of patients involved in the 2 enterically transmitted outbreaks of non-A,non-B hepatitis observed in Algeria and Chad. The third cluster of non-A,non-B hepatitis observed in French soldiers serving in French Guyana is more likely to be attributed to malaria prophylactic treatment with Amodiaquine than to a viral origin. HCV infection was observed in 93% of acute or chronic cases associated with blood transfusion or parenteral drug abuse. Among acute cases, none of the soldiers who contracted the disease in Africa or in French Guyana was found to be anti-HCV positive compared to 78% of those who contracted the disease in France. HCV infections resulted in chronic hepatitis in 61% of cases.
对74名患有非甲非乙型肝炎的法国士兵以及18名在阿尔及利亚参与非甲非乙型肝炎暴发的患者，进行了丙肝病毒（HCV）和戊型肝炎病毒（HEV）血清学标志物的研究。此外，在13名非肠道传播的非甲非乙型肝炎患者中检测到了抗HCV抗体。在阿尔及利亚和乍得观察到的2起经肠道传播的非甲非乙型肝炎暴发事件中，61%-65%的患者接受了HEV抗体检测。在法属圭亚那服役的法国士兵中观察到的第三组非甲非乙型肝炎，更有可能归因于使用阿莫地喹进行疟疾预防性治疗，而非病毒感染。在与输血或非肠道药物滥用相关的急性或慢性病例中，93%观察到HCV感染。在急性病例中，在非洲或法属圭亚那感染该病的士兵中，未发现抗HCV阳性，而在法国感染该病的士兵中这一比例为78%。61%的HCV感染病例发展为慢性肝炎。
