Das C M, Schantz S P, Shillitoe E J
Department of Microbiology, University of Texas Health Science Center Dental Branch, Houston.
Oral Surg Oral Med Oral Pathol. 1993 May;75(5):610-4. doi: 10.1016/0030-4220(93)90235-v.
Cancer of the head and neck has been associated with herpes simplex virus type-1 by serologic studies that have used virus particles or complex mixtures of viral proteins as antigens. Recently a peptide was found to be encoded by the transforming region of the virus that is mutagenic and is postulated to be involved in cell transformation. Sera from young adult patients with head and neck cancer and from control subjects were examined for the presence of antibody to this peptide with the use of an enzyme-linked immunosorbent assay. Antibody to the peptide was detected in many sera and showed a significant correlation with antibody to the virus in sera from control subjects. Antipeptide antibodies were largely of the IgM isotype, and patients had significantly higher levels of antibody than control subjects. This study is consistent with an association between HSV-1 and head and neck cancer and suggests that this viral peptide should be investigated further for its role in carcinogenesis.
血清学研究利用病毒颗粒或病毒蛋白的复杂混合物作为抗原，将头颈部癌症与1型单纯疱疹病毒联系起来。最近发现一种肽由该病毒的转化区域编码，具有致突变性，并推测其参与细胞转化。利用酶联免疫吸附测定法，检测了年轻成年头颈部癌症患者和对照受试者血清中针对该肽的抗体。在许多血清中检测到了针对该肽的抗体，并且与对照受试者血清中针对该病毒的抗体呈显著相关。抗肽抗体主要为IgM同种型，患者的抗体水平显著高于对照受试者。这项研究与HSV-1和头颈部癌症之间的关联一致，并表明应进一步研究这种病毒肽在致癌作用中的作用。
