Larsson P A, Edström S, Westin T, Nordkvist A, Hirsch J M, Vahlne A
Department of Clinical Virology, University of Göteborg, Sweden.
Int J Cancer. 1991 Aug 19;49(1):14-8. doi: 10.1002/ijc.2910490104.
The relation between herpes simplex virus (HSV) and head and neck cancer was examined. A total of ninety patients were analyzed for IgG antibodies against HSV. Antibody titers were established with an enzyme-linked immunosorbent assay and antibodies against specific HSV-antigens were analyzed by Western blot. These patients' seroreactivity was compared to that of an age-matched control group of patients with arteriosclerotic disease in their lower limbs, a disease also closely related to heavy tobacco consumption. Prevalence of antibodies against HSV was around 90% and did not differ significantly between cancer patients and controls, but antibody titers against HSV were significantly higher in the cancer patients. The cancer patients also reacted more constantly (80%) in Western blot analysis against the early immediate protein, ICP-4, than controls (50%). This suggests a different course of an earlier herpetic infection in these patients with a prolonged exposure to early immediate HSV-proteins which may be related to an increased risk of developing head and neck cancer. We propose that heavy smoking may contribute to this phenomenon.
研究了单纯疱疹病毒（HSV）与头颈癌之间的关系。总共对90名患者进行了HSV IgG抗体分析。通过酶联免疫吸附测定确定抗体滴度，并通过蛋白质印迹法分析针对特定HSV抗原的抗体。将这些患者的血清反应性与年龄匹配的下肢动脉硬化疾病患者对照组进行比较，下肢动脉硬化疾病也是一种与大量吸烟密切相关的疾病。HSV抗体的患病率约为90%，癌症患者和对照组之间无显著差异，但癌症患者中HSV抗体滴度显著更高。在蛋白质印迹分析中，癌症患者对早期即刻蛋白ICP-4的反应也比对照组更持续（80%对50%）。这表明这些长期暴露于早期即刻HSV蛋白的患者中，早期疱疹感染的病程不同，这可能与头颈癌发生风险增加有关。我们认为大量吸烟可能导致了这一现象。
