Detection of antibodies of the IgG and IgM classes to herpes simplex virus type 1 in cerebrospinal fluid and serum from four patients with herpes encephalitis.

Antibodies of IgG and IgM classes to Herpes simplex virus type 1 were detected, using the ELISA technique, in the cerebro-spinal fluid (CSF) and in the serum of four patients with encephalitis. All CSF and sera were positive for IgG antibodies; two CSF samples, which were collected quite early, were also positive for antibodies of IgM classes.