Mattina R, Cocuzza C E, Cesana M
Institute of Medical Microbiology, University of Milan, Italy.
Infection. 1993 Mar-Apr;21(2):106-11. doi: 10.1007/BF01710743.
The efficacy and safety of rufloxacin once daily was compared with that of ofloxacin b.i.d. for therapy of complicated cystitis and upper urinary tract infections. Eighty-three patients were randomly assigned to receive rufloxacin as a loading dose of 400 mg on the first day, followed by 200 mg s.i.d., and 80 received ofloxacin 300 mg b.i.d. Both agents were administered orally for a median duration of eight days. Bacterial elimination rates after treatment were 90% for rufloxacin and 81% for ofloxacin. Half of the treatment failures occurred in patients with infections caused by uropathogens that became either less sensitive or resistant to the quinolones being studied. At a two-week follow-up, recurrences had not occurred in any of the rufloxacin patients and had occurred in 17% of the ofloxacin patients. Minor adverse reactions were reported by 12 and 13 patients, respectively. Rufloxacin once daily is as effective as ofloxacin b.i.d. for the treatment of complicated cystitis and upper urinary tract infections.
将每日一次服用芦氟沙星的疗效和安全性与每日两次服用氧氟沙星治疗复杂性膀胱炎和上尿路感染的疗效和安全性进行了比较。83例患者被随机分配，第一天接受400mg芦氟沙星的负荷剂量，随后每日一次服用200mg；80例患者接受每日两次服用300mg氧氟沙星。两种药物均口服给药，中位疗程为8天。治疗后芦氟沙星的细菌清除率为90%，氧氟沙星为81%。一半的治疗失败发生在由对所研究喹诺酮类药物敏感性降低或耐药的尿路致病菌引起感染的患者中。在两周的随访中，芦氟沙星组患者均未复发，而氧氟沙星组患者的复发率为17%。分别有12例和13例患者报告了轻微不良反应。每日一次服用芦氟沙星治疗复杂性膀胱炎和上尿路感染的疗效与每日两次服用氧氟沙星相当。
