Boerema J, Boll B, Muytjens H, Branolte J
J Antimicrob Chemother. 1985 Aug;16(2):211-7. doi: 10.1093/jac/16.2.211.
In an open study 28 patients were treated for complicated UTI with ciprofloxacin 250 mg every 12 h for 10 days. The most frequently isolated species were Escherichia coli and Klebsiella pneumoniae. All pathogens were sensitive to ciprofloxacin in vitro. Twenty-three of the 28 patients (82%) were free of infection 5-9 days after therapy. A persistent infection was noted in two patients (7%) and a reinfection in three patients (11%). Four to six weeks after the end of therapy, 18 patients (64%) were still totally free of infection. Clinical resolution of symptoms and signs occurred in 27 patients (96%). Adverse reactions were spontaneously reported by four of the 28 patients (14%) and by 11 (39%) after detailed inquiry. Most side effects were of gastrointestinal or neurological nature. This small open study supports the view, that ciprofloxacin may be useful in the treatment of complicated UTI.
在一项开放性研究中，28例复杂性尿路感染患者接受环丙沙星治疗，剂量为250毫克，每12小时一次，共10天。最常分离出的菌种是大肠埃希菌和肺炎克雷伯菌。所有病原体在体外对环丙沙星敏感。28例患者中有23例（82%）在治疗后5 - 9天无感染。2例患者（7%）存在持续性感染，3例患者（11%）发生再感染。治疗结束后4至6周，18例患者（64%）仍完全无感染。27例患者（96%）症状和体征临床缓解。28例患者中有4例（14%）自发报告有不良反应，详细询问后有11例（39%）报告有不良反应。大多数副作用为胃肠道或神经方面的。这项小型开放性研究支持以下观点，即环丙沙星可能对治疗复杂性尿路感染有用。
