Mandell W, Neu H C
J Clin Microbiol. 1985 Nov;22(5):786-8. doi: 10.1128/jcm.22.5.786-788.1985.
Ofloxacin, a fluorinated carboxyquinolone, was tested against 485 clinical isolates, and the MICs and disk inhibitory zones were correlated. A critical zone of greater than or equal to 19 mm and an MIC of less than or equal to 2 micrograms/ml indicate susceptibility. An MIC of 4 micrograms/ml and a zone size of 16 to 18 mm is intermediate, and an MIC of greater than or equal to 8 micrograms/ml with a zone size of less than 15 mm indicates resistance. Alternatively, organisms inhibited by an MIC of less than or equal to 4 micrograms/ml with a critical zone diameter of greater than or equal to 15 mm could be considered susceptible. By either of these criteria, major errors in judging susceptibility or resistance are less than 1%.
氧氟沙星，一种氟化羧基喹诺酮类药物，对485株临床分离菌进行了测试，并对其最低抑菌浓度（MIC）和纸片抑菌圈进行了相关性分析。临界抑菌圈直径大于或等于19毫米且MIC小于或等于2微克/毫升表明敏感。MIC为4微克/毫升且抑菌圈大小为16至18毫米为中介，MIC大于或等于8微克/毫升且抑菌圈大小小于15毫米表明耐药。另外，临界抑菌圈直径大于或等于15毫米且MIC小于或等于4微克/毫升时被抑制的菌株可被视为敏感。按照这两种标准中的任何一种，判断敏感或耐药的主要误差均小于1%。
