牛免疫缺陷样病毒长末端重复序列中转录激活反应序列的鉴定
Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus.
作者信息
Carpenter S, Nadin-Davis S A, Wannemuehler Y, Roth J A
机构信息
Department of Microbiology, Immunology, and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011.
出版信息
J Virol. 1993 Jul;67(7):4399-403. doi: 10.1128/JVI.67.7.4399-4403.1993.
Abstract
Transient expression assays using the reporter gene that encodes chloramphenicol acetyltransferase were used to identify cis-acting sequences necessary for bovine immunodeficiency-like virus (BIV) transactivation. Computer analyses identified two RNA stem-loop structures located immediately downstream of the transcription start site in the long terminal repeat. Deletion analysis of the long terminal repeat indicated that sequences containing the proximal stem-loop structure located between +4 and +31 are required for virus-specific transactivation. Therefore, BIV likely utilizes a mechanism of transactivation similar to that of the human and simian lentiviruses.
摘要
使用编码氯霉素乙酰转移酶的报告基因进行的瞬时表达分析，用于鉴定牛免疫缺陷样病毒（BIV）反式激活所需的顺式作用序列。计算机分析确定了位于长末端重复序列转录起始位点紧邻下游的两个RNA茎环结构。长末端重复序列的缺失分析表明，病毒特异性反式激活需要包含位于+4和+31之间的近端茎环结构的序列。因此，BIV可能利用了一种类似于人类和猿猴慢病毒的反式激活机制。
相似文献
1
Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus.牛免疫缺陷样病毒长末端重复序列中转录激活反应序列的鉴定
J Virol. 1993 Jul;67(7):4399-403. doi: 10.1128/JVI.67.7.4399-4403.1993.
2
Activation of bovine immunodeficiency-like virus expression by bovine herpesvirus type 1.1型牛疱疹病毒激活牛免疫缺陷样病毒的表达
Virology. 1992 Apr;187(2):832-6. doi: 10.1016/0042-6822(92)90489-c.
3
Bovine immunodeficiency-like virus encodes factors which trans activate the long terminal repeat.牛免疫缺陷样病毒编码反式激活长末端重复序列的因子。
J Virol. 1992 May;66(5):2647-52. doi: 10.1128/JVI.66.5.2647-2652.1992.
4
Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products.牛免疫缺陷病毒tat基因：两种不同cDNA的克隆以及tat基因产物的鉴定、表征和免疫定位
Virology. 1997 Jul 7;233(2):339-57. doi: 10.1006/viro.1997.8589.
5
Multiple positive and negative cis-acting elements that mediate transactivation by bel1 in the long terminal repeat of human foamy virus.人泡沫病毒长末端重复序列中多个正负顺式作用元件介导bel1反式激活作用。
J Virol. 1993 Apr;67(4):2317-26. doi: 10.1128/JVI.67.4.2317-2326.1993.
6
cis-acting regulatory elements in the bovine immunodeficiency virus long terminal repeat.牛免疫缺陷病毒长末端重复序列中的顺式作用调节元件。
Virology. 1995 Jun 1;209(2):604-14. doi: 10.1006/viro.1995.1292.
7
Bovine immunodeficiency virus: identification of a long terminal repeat sequence with enhanced promoter activity.牛免疫缺陷病毒：具有增强启动子活性的长末端重复序列的鉴定
Arch Virol. 2009;154(7):1163-7. doi: 10.1007/s00705-009-0411-z. Epub 2009 Jun 23.
8
The bovine immunodeficiency virus: cloning of a tat/rev cDNA encoding a novel Tat protein with enhanced transactivation activity.牛免疫缺陷病毒：编码具有增强反式激活活性的新型Tat蛋白的tat/rev cDNA的克隆
Arch Virol. 2005 Aug;150(8):1529-47. doi: 10.1007/s00705-005-0522-0. Epub 2005 Apr 13.
9
Identification and characterization of the bovine immunodeficiency-like virus tat gene.牛免疫缺陷样病毒tat基因的鉴定与特征分析
J Virol. 1992 Aug;66(8):5137-40. doi: 10.1128/JVI.66.8.5137-5140.1992.
10
cis-acting regulatory regions in the long terminal repeat of simian foamy virus type 1.猴泡沫病毒1型长末端重复序列中的顺式作用调控区域。
J Virol. 1992 Jan;66(1):251-7. doi: 10.1128/JVI.66.1.251-257.1992.
引用本文的文献
1
2
A single intermolecular contact mediates intramolecular stabilization of both RNA and protein.单个分子间接触介导RNA和蛋白质的分子内稳定化。
Proc Natl Acad Sci U S A. 2005 May 10;102(19):6849-54. doi: 10.1073/pnas.0409282102. Epub 2005 Apr 27.
3
Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions.具有异源反式激活因子-反式激活应答元件相互作用的人类免疫缺陷病毒的复制
J Virol. 2003 Feb;77(3):1984-91. doi: 10.1128/jvi.77.3.1984-1991.2003.
4
Binding of Tat to TAR and recruitment of positive transcription elongation factor b occur independently in bovine immunodeficiency virus.在牛免疫缺陷病毒中，Tat与TAR的结合以及正转录延伸因子b的募集是独立发生的。
J Virol. 2000 Jul;74(13):6039-44. doi: 10.1128/jvi.74.13.6039-6044.2000.
5
Characterization of the Jembrana disease virus tat gene and the cis- and trans-regulatory elements in its long terminal repeats.詹博拉纳病病毒tat基因及其长末端重复序列中的顺式和反式调控元件的特征分析。
J Virol. 1999 Jan;73(1):658-66. doi: 10.1128/JVI.73.1.658-666.1999.
6
A common mechanism for the enhancement of mRNA 3' processing by U3 sequences in two distantly related lentiviruses.两种远亲慢病毒中U3序列增强mRNA 3'加工的常见机制。
J Virol. 1996 Mar;70(3):1612-7. doi: 10.1128/JVI.70.3.1612-1617.1996.
本文引用的文献
1
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.人嗜T淋巴细胞病毒长末端重复序列在受感染细胞中的反式作用转录激活
Science. 1984 Jul 27;225(4660):381-5. doi: 10.1126/science.6330891.
2
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.劳氏肉瘤病毒长末端重复序列通过DNA介导转染导入多种真核细胞时是一个强启动子。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6777-81. doi: 10.1073/pnas.79.22.6777.
3
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.用核酸外切酶III进行单向消化可为DNA测序创建靶向断点。
Gene. 1984 Jun;28(3):351-9. doi: 10.1016/0378-1119(84)90153-7.
4
Isolation of a virus from cattle with persistent lymphocytosis.从患持续性淋巴细胞增多症的牛中分离出一种病毒。
J Natl Cancer Inst. 1972 Dec;49(6):1649-57. doi: 10.1093/jnci/49.6.1649.
5
Rapid and efficient site-specific mutagenesis without phenotypic selection.无需表型筛选的快速高效位点特异性诱变。
Proc Natl Acad Sci U S A. 1985 Jan;82(2):488-92. doi: 10.1073/pnas.82.2.488.
6
Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus.一种与人类免疫缺陷病毒相关的牛慢病毒的鉴定及分子克隆
Nature. 1987;330(6146):388-91. doi: 10.1038/330388a0.
7
Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.参与人类免疫缺陷病毒转录调控的细胞蛋白之间的相互作用。
EMBO J. 1987 Dec 1;6(12):3761-70. doi: 10.1002/j.1460-2075.1987.tb02711.x.
8
HIV-1 tat trans-activation requires the loop sequence within tar.HIV-1反式激活转录蛋白（tat）的反式激活作用需要tar内的环序列。
Nature. 1988 Jul 14;334(6178):165-7. doi: 10.1038/334165a0.
9
Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.人类免疫缺陷病毒1型5'非编码区的突变分析：二级结构对翻译的影响
EMBO J. 1988 Sep;7(9):2831-7. doi: 10.1002/j.1460-2075.1988.tb03139.x.
10
Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity.一种用于人类免疫缺陷病毒感染性的灵敏定量焦点测定法的开发。
J Virol. 1988 Oct;62(10):3779-88. doi: 10.1128/JVI.62.10.3779-3788.1988.
Zotero 插件