同步性原发性肺癌：手术材料中的患病率及临床意义
Synchronous primary lung cancers: prevalence in surgical material and clinical implications.
作者信息
Carey F A, Donnelly S C, Walker W S, Cameron E W, Lamb D
机构信息
Department of Pathology, University of Edinburgh.
出版信息
Thorax. 1993 Apr;48(4):344-6. doi: 10.1136/thx.48.4.344.
BACKGROUND
The prevalence of synchronous primary lung neoplasms in surgical resection specimens was assessed. The associated clinical features and prognostic implications were investigated.
METHODS
All surgical resections for lung cancer performed during seven years were reviewed. Synchronous tumours were defined by the presence of more than one tumour mass in the lung, by differences in histological subtype, by the presence of separate bronchial origins, or by differences in DNA stemlines. Clinical data were abstracted from case notes and information from the tumour registry.
RESULTS
Just under 2% of all surgical specimens in the study period contained more than one primary carcinoma. The patients did not differ clinically from the general population of patients having surgery for lung cancer. The overall prognosis was poor (mean survival 27 months) but was significantly better for patients with synchronous squamous carcinomas (mean survival 49 months).
CONCLUSION
Synchronous primary lung carcinomas are associated with a poor prognosis except in patients having tumours only of squamous histological type.
背景
评估手术切除标本中同步性原发性肺肿瘤的患病率。研究相关临床特征及预后影响。
方法
回顾七年间所有肺癌手术切除病例。同步性肿瘤定义为肺内存在一个以上肿瘤灶、组织学亚型不同、支气管起源不同或DNA干细胞系不同。临床数据从病例记录中提取，肿瘤登记信息亦如此。
结果
研究期间所有手术标本中略低于2%含有一个以上原发性癌。这些患者在临床方面与接受肺癌手术的普通患者群体无差异。总体预后较差（平均生存27个月），但同步性鳞状细胞癌患者的预后明显较好（平均生存49个月）。
结论
同步性原发性肺癌预后较差，鳞状组织学类型肿瘤患者除外。
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