Kakizoe T, Matumoto K, Nishio Y, Ohtani M, Kishi K
J Urol. 1985 Mar;133(3):395-8. doi: 10.1016/s0022-5347(17)48994-4.
Cystectomy specimens of 118 transitional cell carcinomas of the bladder were analyzed by step-sectioning. The carcinoma in situ and dysplasia adjacent to and remote from the visible bladder cancer were correlated with the tumor configuration on cystoscopy, and grade and stage of the disease. Results showed that a combination of papillary and nodular carcinomas in a single bladder was associated with a high incidence of mucosal involvement. Moreover, more than 50 per cent of all grade 3 carcinomas were associated with carcinoma in situ and dysplasia adjacent to and remote from the visible tumors. Carcinoma in situ and dysplasia were not related to the stage of disease. For management of bladder cancer, it appears important to assess the gross configuration of tumors by cystophotography and to determine the grade of tumors by biopsy, because mucosal involvement was found to be correlated closely with the tumor configuration and grade 3 disease.
对118例膀胱移行细胞癌的膀胱切除术标本进行了连续切片分析。将原位癌以及与肉眼可见的膀胱癌相邻和远离部位的发育异常与膀胱镜检查时的肿瘤形态、疾病分级和分期进行关联分析。结果显示，单个膀胱内乳头状癌和结节状癌并存与黏膜受累的高发生率相关。此外，所有3级癌中超过50%与原位癌以及与肉眼可见肿瘤相邻和远离部位的发育异常相关。原位癌和发育异常与疾病分期无关。对于膀胱癌的治疗，通过膀胱造影评估肿瘤的大体形态以及通过活检确定肿瘤分级似乎很重要，因为发现黏膜受累与肿瘤形态和3级疾病密切相关。
