Crawley J M, Bishop R F, Barnes G L
Department of Gastroenterology, Royal Children's Hospital, Parkville, Victoria, Australia.
J Paediatr Child Health. 1993 Jun;29(3):219-21. doi: 10.1111/j.1440-1754.1993.tb00491.x.
The aim of this study was to determine the occurrence of rotavirus infection in infants under 6 months of age who were admitted to hospital in a developed country for treatment of gastroenteritis. Between April 1980 and April 1990, 595 such infants were admitted to the infectious diseases ward at the Royal Children's Hospital, Melbourne, Australia. Faecal specimens were collected within 6 h of admission and were tested for viral, bacterial and protozoal enteric pathogens. Rotaviruses of several serotypes were found in specimens from 15.1% of the infants, adenoviruses in 12.4% and other pathogens in 10.8%. Rotaviruses were found equally often in infants in each 1 month age group. No pathogens were able to be identified in 61.7% of cases. These results show that rotavirus is an important pathogen in infants under 6 months of age who are admitted to hospital with gastroenteritis. Rotavirus vaccination will need to be given during the first 1-3 months of life in developed countries, as is recommended for developing countries. The large group in whom no pathogens were isolated requires further consideration.
本研究的目的是确定在一个发达国家因患肠胃炎而住院治疗的6个月以下婴儿中轮状病毒感染的发生率。1980年4月至1990年4月期间，595名此类婴儿被收治到澳大利亚墨尔本皇家儿童医院的传染病病房。入院后6小时内采集粪便样本，检测其中的病毒、细菌和原生动物肠道病原体。在15.1%的婴儿样本中发现了几种血清型的轮状病毒，12.4%的样本中发现了腺病毒，10.8%的样本中发现了其他病原体。在每个1月龄组的婴儿中，轮状病毒的检出率相同。61.7%的病例中未发现病原体。这些结果表明，轮状病毒是因肠胃炎住院的6个月以下婴儿中的一种重要病原体。在发达国家，正如对发展中国家所建议的那样，需要在婴儿出生后的头1至3个月内接种轮状病毒疫苗。未分离出病原体的这一庞大群体需要进一步研究。
