通过丙型肝炎病毒核糖核酸（HCV-RNA）分析检测到的丙型肝炎病毒（HCV）垂直传播。
Vertical transmission of hepatitis C virus (HCV) detected by HCV-RNA analysis.
作者信息
Kuroki T, Nishiguchi S, Fukuda K, Ikeoka N, Murata R, Isshiki G, Tomoda S, Ogita S, Monna T, Kobayashi K
机构信息
Osaka City University Medical School, Japan.
出版信息
Gut. 1993;34(2 Suppl):S52-3. doi: 10.1136/gut.34.2_suppl.s52.
The rate of transmission of hepatitis C virus (HCV) from patients with chronic hepatitis C to their children was studied. Of the 64 children with a parent with chronic hepatitis C, two (3%) had abnormal alanine aminotransferase (ALT) activities, six (9%) had anti-HCV detected by c100 ELISA, seven (11%) had anti-HCV detected by ELISA-II, and 21 (33%) had HCV-RNA by polymerase chain reaction (PCR). Anti-HCV detected by ELISA-II disappeared within six months in all six infants. Of the five children whose mothers were given a blood transfusion after the child's first birthday, none had anti-HCV or HCV-RNA. In the five families whose elder or eldest offspring had HCV-RNA, all of the younger offspring had HCV-RNA. The vertical transmission rate of HCV was low if judged by the presence of anti-HCV or abnormal ALT values, but the rate was high (33%) if judged by the presence of HCV-RNA.
对慢性丙型肝炎患者向其子女传播丙型肝炎病毒（HCV）的比率进行了研究。在64名父母患有慢性丙型肝炎的儿童中，两名（3%）丙氨酸转氨酶（ALT）活性异常，6名（9%）通过c100酶联免疫吸附测定（ELISA）检测到抗HCV，7名（11%）通过第二代ELISA检测到抗HCV，21名（33%）通过聚合酶链反应（PCR）检测到HCV-RNA。通过第二代ELISA检测到的抗HCV在所有6名婴儿中6个月内消失。在5名母亲在孩子一岁生日后接受输血的儿童中，无人检测到抗HCV或HCV-RNA。在5个年长或最大子女有HCV-RNA的家庭中，所有年幼子女均有HCV-RNA。如果根据抗HCV或ALT值异常来判断，HCV的垂直传播率较低，但如果根据HCV-RNA的存在来判断，该比率较高（33%）。
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