Gallice P, Lai E, Brunet P, Berland Y, Elsen R, Crevat A
Biophysics Laboratory, Faculty of Pharmacy, Marseille, France.
Int J Artif Organs. 1993 Mar;16(3):120-2.
A uremic toxin fraction (fraction 2-3-1) in the middle molecular mass range (300-2000 Da) containing a sodium potassium inhibitor pump was studied. As fraction 2-3-1 was known to be present in minute quantities in urine and plasma, erythrocyte lysates were used as an alternative source. Results show that fraction 2-3-1 is more abundant in erythrocytes than in normal urine. In addition, the fraction is present in a greater quantity in uremic erythrocytes than in normal blood cells. It is concluded that fraction 2-3-1 is concentrated at the erythrocyte level in uremic patients.
对一种分子量处于中等范围（300 - 2000道尔顿）、含有钠钾抑制泵的尿毒症毒素组分（组分2 - 3 - 1）进行了研究。由于已知组分2 - 3 - 1在尿液和血浆中含量极少，因此使用红细胞裂解物作为替代来源。结果表明，组分2 - 3 - 1在红细胞中的含量比正常尿液中更为丰富。此外，该组分在尿毒症患者的红细胞中的含量高于正常血细胞。得出的结论是，组分2 - 3 - 1在尿毒症患者的红细胞水平上被浓缩。
