Röther E, Galle J, Peter H H
Abteilung für Rheumatologie, Medizinische Universitätsklinik Freiburg.
Immun Infekt. 1993 Jun;21(3):59-63.
Raynaud's phenomenon (RP) is an episodic digital ischemia provoked by internal and/or external stressors. While the primary RP occurs independently of other diseases and appears to be mediated by a vegetative imbalance of the peripheral vasomotor tone, the secondary RP is often part of an underlying disorder, especially of collagen-vascular diseases such as SLE or scleroderma. Vascular involvement in the pathogenesis of connective tissue diseases is well known but poorly understood. Endothelium injury by autoantibodies and circulating immune complexes may play a central but not sufficient role in the pathogenesis of secondary RP. In this review, epidemiology and diagnosis of RP secondary to connective tissues diseases are described and new pathogenic concepts are discussed in view of current knowledge on endothelial function.
雷诺现象（RP）是一种由内部和/或外部应激源引发的发作性指端缺血。原发性RP独立于其他疾病发生，似乎由外周血管舒缩张力的自主神经失衡介导，而继发性RP通常是潜在疾病的一部分，尤其是如系统性红斑狼疮或硬皮病等胶原血管疾病。血管受累在结缔组织病发病机制中是众所周知的，但了解甚少。自身抗体和循环免疫复合物导致的内皮损伤可能在继发性RP发病机制中起核心作用，但并非充分条件。在本综述中，描述了结缔组织病继发RP的流行病学和诊断，并根据目前关于内皮功能的知识讨论了新的致病概念。
