Piepkorn M, Kumasaka B, Krieger J N, Burmer G C
Department of Medicine (Dermatology), University of Washington School of Medicine, Seattle 98195.
J Am Acad Dermatol. 1993 Aug;29(2 Pt 2):321-5. doi: 10.1016/0190-9622(93)70186-w.
Buschke-Löwenstein-type giant penile condyloma developed in a human immunodeficiency virus-negative, 25-year-old man after 4 years of intermittent cyclosporine therapy (5 mg/kg/day) for pustular psoriasis. Microscopic examination showed multifocal areas of invasive squamous cell carcinoma. Dot blot analysis of amplified polymerase chain reaction products with primers directed at the L1 region demonstrated signals for several human papillomavirus genotypes, including human papillomavirus type 16, that correlated with different histologic patterns consisting of verrucous and bowenoid changes and invasive carcinoma. This case conforms to the enhanced risk of cutaneous carcinogenesis from either papillomavirus infection or chronic actinic damage that has become evident in patients with organ allografts and cyclosporine therapy.
一名25岁的人类免疫缺陷病毒阴性男性，因脓疱型银屑病接受了4年的间歇性环孢素治疗（5毫克/千克/天）后，发生了Buschke-Löwenstein型巨大阴茎尖锐湿疣。显微镜检查显示为浸润性鳞状细胞癌的多灶性区域。用针对L1区域的引物对聚合酶链反应扩增产物进行斑点印迹分析，结果显示了几种人乳头瘤病毒基因型的信号，包括16型人乳头瘤病毒，这些信号与由疣状和鲍温样改变及浸润性癌组成的不同组织学模式相关。该病例符合在接受器官移植和环孢素治疗的患者中已明显出现的因乳头瘤病毒感染或慢性光化性损伤而导致皮肤癌发生风险增加的情况。
