挪威一家硝酸盐化肥厂工人的癌症发病率。
Incidence of cancer among workers in a Norwegian nitrate fertiliser plant.
作者信息
Fandrem S I, Kjuus H, Andersen A, Amlie E
机构信息
Department of Occupational Medicine, Telemark Central Hospital, Porsgrunn, Norway.
出版信息
Br J Ind Med. 1993 Jul;50(7):647-52. doi: 10.1136/oem.50.7.647.
The incidence of cancer among 2023 male fertiliser workers has been investigated in a historical cohort study. Workers who had been employed for more than one year in work with possible exposure to dust containing nitrate between 1945 and 1979 were included. An individual cumulated exposure to dust expressed in level-years was calculated for each participant. The cohort was followed up from 1953 to the end of 1988, and the incidence of cancer was compared with the national rates. There were 467 deaths v 504.8 expected (standardised mortality ratio (SMR) = 0.93), and 185 cases of cancer v 195.5 expected (standardised incidence ratio (SIR) = 0.95). Thirty cases of lung cancer were found v 27.5 expected (SIR = 1.09). No overall excess of gastric cancer was found (15 cases v 17.0 expected; SIR = 0.89). No association was found between cumulated exposure to nitrate and gastric cancer, and there was no association between duration of employment or time since first employment and incidence of gastric cancer.
在一项历史性队列研究中，对2023名男性化肥工人的癌症发病率进行了调查。纳入了1945年至1979年间在可能接触含硝酸盐粉尘的工作中工作超过一年的工人。为每位参与者计算了以水平年表示的个体累积粉尘暴露量。该队列从1953年随访至1988年底，并将癌症发病率与全国发病率进行了比较。死亡467例，预期504.8例（标准化死亡率（SMR）=0.93），癌症病例185例，预期195.5例（标准化发病率（SIR）=0.95）。发现肺癌30例，预期27.5例（SIR=1.09）。未发现胃癌总体超额（15例，预期17.0例；SIR=0.89）。未发现硝酸盐累积暴露与胃癌之间存在关联，且就业持续时间或首次就业以来的时间与胃癌发病率之间也无关联。
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