肝移植受者中HLA抗原DR3与α1-抗胰蛋白酶缺乏症之间无关联。
Lack of association between HLA antigen DR3 and alpha 1-antitrypsin deficiency in liver transplant recipients.
作者信息
Casavilla A, Gordon R, van Thiel D H, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania.
出版信息
Dig Dis Sci. 1993 Aug;38(8):1489-91. doi: 10.1007/BF01308609.
The relationship between alpha 1-antitrypsin deficiency (alpha 1-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for alpha 1-AT ZZ, no such association was seen in this population of alpha 1-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for alpha 1-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of alpha 1-AT.
在32例肝移植受者中研究了α1-抗胰蛋白酶缺乏症（α1-ATD）与HLA抗原系统之间的关系。尽管先前有报道称HLA抗原DR3与α1-AT ZZ纯合性相关，但在这群患有晚期肝病的α1-ATD纯合ZZ患者中未观察到这种关联。因此，所报道的HLA II类抗原与α1-AT Z等位基因纯合性之间的关联可能是小样本研究人群或地理近亲繁殖的假象，以及某些HLA抗原与α1-AT Z等位基因纯合性存在的偶然关联。
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