Chiarugi V, Dello Sbarba P, Magnelli L, Chiarugi P, Pacini S, Ruggiero M
Laboratory of Molecular Biology, University of Florence.
Tumori. 1993 Apr 30;79(2):92-9. doi: 10.1177/030089169307900202.
Novel aspects of cytokine receptor signal transduction are discussed and cytokine receptors classified based on ligand-dependent signalling. An introductory section presents an overview of the role of cytokines in hematopoiesis. A brief explanation of basic concepts, such as redundancy, pleiotropy, synergism, etc., important for the understanding of cell response to cytokines, is also included. Three of five classes of receptors show the involvement of tyrosine kinase activity as the key step in signal transduction. The importance of tyrosine phosphorylation in cellular response to cytokines is pointed out.
讨论了细胞因子受体信号转导的新方面，并根据配体依赖性信号传导对细胞因子受体进行了分类。引言部分概述了细胞因子在造血中的作用。还简要解释了冗余、多效性、协同作用等基本概念，这些概念对于理解细胞对细胞因子的反应很重要。五类受体中的三类显示酪氨酸激酶活性的参与是信号转导的关键步骤。指出了酪氨酸磷酸化在细胞对细胞因子反应中的重要性。
