细胞因子受体信号转导与造血细胞发育的调控
Cytokine receptor signal transduction and the control of hematopoietic cell development.
作者信息
Watowich S S, Wu H, Socolovsky M, Klingmuller U, Constantinescu S N, Lodish H F
机构信息
Department of Immunology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Annu Rev Cell Dev Biol. 1996;12:91-128. doi: 10.1146/annurev.cellbio.12.1.91.
The cytokine receptor superfamily is characterized by structural motifs in the exoplasmic domain and by the absence of catalytic activity in the cytosolic segment. Activated by ligand-triggered multimerization, these receptors in turn activate a number of cytosolic signal transduction proteins, including protein tyrosine kinases and phosphatases, and affect an array of cellular functions that include proliferation and differentiation. Molecular study of these receptors is revealing the roles they play in the control of normal hematopoiesis and in the development of disease.
细胞因子受体超家族的特征在于胞外结构域中的结构基序以及胞质段中缺乏催化活性。这些受体通过配体触发的多聚化而被激活，进而激活多种胞质信号转导蛋白，包括蛋白酪氨酸激酶和磷酸酶，并影响一系列细胞功能，包括增殖和分化。对这些受体的分子研究正在揭示它们在正常造血控制和疾病发展中所起的作用。
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