Jaeger U, Kapiotis S, Pabinger I, Puchhammer E, Kyrle P A, Lechner K
Department of Medicine I, University of Vienna, Austria.
Ann Hematol. 1993 Aug;67(2):95-9. doi: 10.1007/BF01788133.
A potent lupus anticoagulant (LA) was detected in four children, 1 week after the clinical onset of an adenovirus infection. The adenovirus infection was documented by direct virus detection in the stool of one patient and serologically in the others. None of the children had elevated titers of IgM- and only one of IgG-anticardiolipin antibodies (ACA). All patients had a marked reduction of prothrombin activity as well as antigen. Prothrombin-antibody complexes were demonstrated in the patients' plasma or mixtures of patient and normal plasma. Factor XII activity was moderately reduced in three of the patients. All coagulation abnormalities returned to normal within 4-12 weeks. Localized bleeding was observed in two cases, but there was no generalized bleeding tendency or evidence of thrombosis.
在4名儿童腺病毒感染临床发病1周后，检测到一种强效狼疮抗凝物（LA）。通过直接检测1名患者粪便中的病毒及血清学检测其他患者，证实了腺病毒感染。所有儿童的IgM滴度均未升高，只有1名儿童的IgG抗心磷脂抗体（ACA）升高。所有患者的凝血酶原活性及抗原均显著降低。在患者血浆或患者与正常血浆的混合物中证实存在凝血酶原 - 抗体复合物。3名患者的因子Ⅻ活性中度降低。所有凝血异常在4 - 12周内恢复正常。2例观察到局部出血，但无全身出血倾向或血栓形成迹象。
