Rowe E L, Machkovech S M
J Pharm Sci. 1977 Feb;66(2):273-5. doi: 10.1002/jps.2600660236.
The acetylation of clindamycin palmitate hydrochloride, preparatory to GLC assay, was accelerated greatly by the use of 4-(dimethylamino)pyridine as a catalyst. The reaction time was reduced from 2.5 hr at 100 degrees using pyridine and acetic anhydride to 30 min or less at ambient temperature upon addition of excess catalyst.
在进行气相色谱分析（GLC）测定之前，使用4-（二甲基氨基）吡啶作为催化剂可大大加速盐酸克林霉素棕榈酸酯的乙酰化反应。反应时间从使用吡啶和乙酸酐在100℃下反应2.5小时，缩短至加入过量催化剂后在室温下30分钟或更短时间。
