Sakai H, Mochizuki K, Torisaki M
Department of Ophthalmology, Kanazawa University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Jul;97(7):812-9.
The effects of lomefloxacin on the in-vitro ERG were studied in the rabbit. The ERG was unchanged during perfusion with 100 microM lomefloxacin. The oscillatory potential was selectively diminished with 300 microM lomefloxacin. The suppressive effect of 300 microM lomefloxacin on the oscillatory potential was antagonized by 0.2 microM bicuculline or 0.2 microM picrotoxin. Bicuculline (0.2 microM) or picrotoxin (0.2 microM) antagonized the suppressive effect of GABA (50 microM) on the oscillatory potential. Bicuculline (1.0 microM) alone, picrotoxin (1.0 microM) alone or GABA (50 microM) alone did not augment the oscillatory potential. The findings of the present study suggested that lomefloxacin, a new quinolone agent, inhibits GABA receptor binding in the rabbit retina.
在兔子身上研究了洛美沙星对体外视网膜电图（ERG）的影响。在用100微摩尔洛美沙星灌注期间，ERG无变化。300微摩尔洛美沙星可选择性地降低振荡电位。0.2微摩尔荷包牡丹碱或0.2微摩尔印防己毒素可拮抗300微摩尔洛美沙星对振荡电位的抑制作用。荷包牡丹碱（0.2微摩尔）或印防己毒素（0.2微摩尔）可拮抗γ-氨基丁酸（GABA，50微摩尔）对振荡电位的抑制作用。单独使用1.0微摩尔荷包牡丹碱、1.0微摩尔印防己毒素或50微摩尔GABA均不会增强振荡电位。本研究结果表明，新型喹诺酮类药物洛美沙星可抑制兔视网膜中的GABA受体结合。
