脑心肌炎病毒D变种（EMC-D）在小鼠中的传播性。

Transmissibility of the D variant of encephalomyocarditis virus (EMC-D) in mice.

作者信息

Doi C, Takeda M, Hirasawa K, Doi K

机构信息

Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.

出版信息

Lab Anim. 1993 Jul;27(3):222-5. doi: 10.1258/002367793780745480.

DOI:10.1258/002367793780745480

PMID:8396185

Abstract

Transmissibility of the D variant of encephalomyocarditis virus (EMC-D) was examined. Eight-week-old ICR:CD-1 male mice inoculated with 10(5) plaque forming units (PFU)/animal of EMC-D intranasally, orally or intraperitoneally showed marked viraemia and prominent pancreatic lesions at 2 days after inoculation (2 DAI), and excreted virus in faeces from 2 to 8 DAI (virus titre: 10(3)-10(5) PFU/g). Only a small proportion of control mice housed with EMC-D-inoculated mice for 10 days developed viraemia and pancreatic lesions.

摘要

对脑心肌炎病毒D型变种（EMC-D）的传播性进行了检测。8周龄的ICR:CD-1雄性小鼠经鼻内、口服或腹腔内接种10⁵空斑形成单位（PFU）/动物的EMC-D后，在接种后2天（2 DAI）出现明显的病毒血症和显著的胰腺病变，并在2至8 DAI期间从粪便中排出病毒（病毒滴度：10³-10⁵ PFU/g）。与接种EMC-D的小鼠共同饲养10天的对照小鼠中，只有一小部分出现了病毒血症和胰腺病变。