Ohta H, Matsumoto K, Watanabe H, Shimizu M
Section of Pharmacology, Research Institute for Wakan-Yaku, Japan.
Jpn J Pharmacol. 1993 Jun;62(2):199-202. doi: 10.1254/jjp.62.199.
Paeoniflorin, a major constituent of peony root (1 mg/kg, p.o.), attenuated scopolamine-induced deficit in radial maze performance. Both prazosin (0.5 mg/kg, i.p.) and yohimbine (0.3 mg/kg, i.p.) neither impaired radial maze performance by itself nor augmented the scopolamine-induced performance deficit. Prazosin significantly blocked the antagonizing effect of paeoniflorin on the scopolamine deficit, whereas yohimbine did not affect the paeoniflorin effect. These data suggest that the alpha 1-adrenergic but not alpha 2-adrenergic systems are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze performance in rats.
芍药苷是芍药根的主要成分（口服，1毫克/千克），可减轻东莨菪碱诱导的放射状迷宫行为表现缺陷。哌唑嗪（腹腔注射，0.5毫克/千克）和育亨宾（腹腔注射，0.3毫克/千克）单独使用时既不损害放射状迷宫行为表现，也不加剧东莨菪碱诱导的行为表现缺陷。哌唑嗪显著阻断了芍药苷对东莨菪碱缺陷的拮抗作用，而育亨宾不影响芍药苷的作用。这些数据表明，α1-肾上腺素能系统而非α2-肾上腺素能系统参与了芍药苷对大鼠放射状迷宫行为中东莨菪碱缺陷的拮抗作用。
