Ohta H, Matsumoto K, Shimizu M, Watanabe H
Division of Pharmacology, (Oriental Medicines), Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Pharmacol Biochem Behav. 1994 Sep;49(1):213-7. doi: 10.1016/0091-3057(94)90478-2.
The effects of paeoniflorin isolated from peony were examined on an aging-induced learning deficit in an operant brightness discrimination task in Fischer 344 rats. Learning in aged (25 months) rats was significantly impaired compared with young (5 months) rats. Daily administration of paeoniflorin (0.01 mg/kg, PO) significantly attenuated the learning impairment in aged rats, whereas it did not affect the learning in young rats. Although tacrine (0.3 and 1 mg/kg, IP), a cholinesterase inhibitor, also did not affect the learning in young rats, it slightly augmented the aging-induced learning deficit in the present task. These data indicate the therapeutic potential of paeoniflorin in the treatment of senile dementia and aging-induced cognitive dysfunction.
研究了从芍药中分离出的芍药苷对Fischer 344大鼠在操作性亮度辨别任务中衰老诱导的学习缺陷的影响。与年轻（5个月）大鼠相比，老年（25个月）大鼠的学习能力明显受损。每日给予芍药苷（0.01 mg/kg，口服）可显著减轻老年大鼠的学习障碍，而对年轻大鼠的学习没有影响。虽然胆碱酯酶抑制剂他克林（0.3和1 mg/kg，腹腔注射）对年轻大鼠的学习也没有影响，但在本实验中它略微加重了衰老诱导的学习缺陷。这些数据表明芍药苷在治疗老年痴呆和衰老诱导的认知功能障碍方面具有治疗潜力。
