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Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine.

作者信息

Watanabe H

机构信息

Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.

出版信息

Behav Brain Res. 1997 Feb;83(1-2):135-41. doi: 10.1016/s0166-4328(97)86057-3.

DOI:10.1016/s0166-4328(97)86057-3
PMID:9062672
Abstract

A traditional Chinese medicine, Shimotsu-to, consisting of four herbs: Japanese angelica root, cnidium rhizome, peony root and rehmannia root, has been reported to improve spatial working memory in rats. The present results indicate that Paeoniflorin and tetramethylpyrazine (TMP) extracted from peony root and cnidium rhizome, respectively, are candidates for cognitive enhancer.

摘要

相似文献

1
Candidates for cognitive enhancer extracted from medicinal plants: paeoniflorin and tetramethylpyrazine.
Behav Brain Res. 1997 Feb;83(1-2):135-41. doi: 10.1016/s0166-4328(97)86057-3.
2
Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats.
Pharmacol Biochem Behav. 1993 Jul;45(3):719-23. doi: 10.1016/0091-3057(93)90530-7.
3
Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task.芍药苷可减轻老年大鼠在操作性亮度辨别任务中的学习障碍。
Pharmacol Biochem Behav. 1994 Sep;49(1):213-7. doi: 10.1016/0091-3057(94)90478-2.
4
Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora.芍药苷和8-去苯甲酰基芍药苷（来自芍药根的糖苷）的降血糖作用。
Planta Med. 1997 Aug;63(4):323-5. doi: 10.1055/s-2006-957692.
5
Involvement of alpha 1- but not alpha 2-adrenergic systems in the antagonizing effect of paeoniflorin on scopolamine-induced deficit in radial maze performance in rats.芍药苷对东莨菪碱所致大鼠放射状迷宫行为缺陷的拮抗作用涉及α1-而非α2-肾上腺素能系统。
Jpn J Pharmacol. 1993 Jun;62(2):199-202. doi: 10.1254/jjp.62.199.
6
Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo.芍药苷的抗血栓形成作用：在体内光化学反应血栓形成模型中进行评估。
Planta Med. 2001 Nov;67(8):766-7. doi: 10.1055/s-2001-18364.
7
Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells.中药四物汤及其成分川芎和衍生化合物对小鼠主动脉平滑肌细胞原代培养物的抗增殖作用。
Jpn J Pharmacol. 1992 Dec;60(4):397-401. doi: 10.1254/jjp.60.397.
8
Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice.芍药苷是芍药根的主要成分，可逆转毒蕈碱M1受体拮抗剂诱导的大鼠海马脑片长时程增强抑制。
Jpn J Pharmacol. 2000 May;83(1):25-30. doi: 10.1254/jjp.83.25.
9
Involvement of beta-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radial maze performance in rats.β-肾上腺素能系统参与芍药苷对东莨菪碱所致大鼠放射状迷宫行为缺损的拮抗作用。
Jpn J Pharmacol. 1993 Aug;62(4):345-9. doi: 10.1254/jjp.62.345.
10
Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats.芍药苷通过激活Wistar大鼠中枢腺苷A1受体逆转胍乙啶诱导的低血压。
Clin Exp Pharmacol Physiol. 1999 Oct;26(10):815-6. doi: 10.1046/j.1440-1681.1999.03132.x.

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