Del Bigio M R, Deck J H
Division of Neuropathology, Toronto Hospital, University of Toronto, Canada.
Acta Neuropathol. 1993;86(1):100-4. doi: 10.1007/BF00454907.
In this report we describe a glioblastoma multiforme with focal granular cell change. In most astroglial tumors with granular cells, the granular appearance is due to the presence of periodic acid-Schiff-positive, membrane-bound cellular debris. In the present case the granular appearance was due to the presence of many small Rosenthal fibers, which were immunoreactive for glial fibrillary acidic protein, vimentin, ubiquitin, and heat-shock protein 27, but not for alpha-B crystallin. The ultrastructural characteristics are described. These findings demonstrate that granulofilamentous inclusions with the appearance of Rosenthal fibers in glial tumors are a structurally heterogeneous feature.
在本报告中，我们描述了一例伴有局灶性颗粒细胞改变的多形性胶质母细胞瘤。在大多数伴有颗粒细胞的星形胶质细胞瘤中，颗粒状外观是由于存在过碘酸希夫氏阳性、膜结合的细胞碎片。在本例中，颗粒状外观是由于存在许多小的罗森塔尔纤维，这些纤维对胶质纤维酸性蛋白、波形蛋白、泛素和热休克蛋白27呈免疫反应，但对α - B晶状体蛋白无免疫反应。本文描述了其超微结构特征。这些发现表明，胶质肿瘤中具有罗森塔尔纤维外观的颗粒丝状包涵体是一种结构异质性特征。
