环磷酸腺苷可能参与调节波氏拟小克银汉霉中NADP⁺/NAD⁺-谷氨酸脱氢酶的比例以及酵母-菌丝体转变过程。
Possible involvement of cyclic adenosine 3',5'-monophosphate in the regulation of NADP-/NAD-glutamate dehydrogenase ratio and in yeast-mycelium transition of Benjaminiella poitrasii.
作者信息
Khale-Kumar A, Deshpande M V
机构信息
Biochemical Sciences Division, National Chemical Laboratory, Pune, India.
出版信息
J Bacteriol. 1993 Sep;175(18):6052-5. doi: 10.1128/jb.175.18.6052-6055.1993.
Abstract
The effect of different adenine-containing compounds on the NADP-/NAD-glutamate dehydrogenase (GDH) ratio was studied as a function of yeast-mycelium transition in Benjaminiella poitrasii. Under in vivo conditions, at a 5.0 mM concentration, cyclic AMP (cAMP) and dibutyryl cAMP maintained the cells in the yeast form for up to 7 and 5 h, respectively, and this was reflected in the patterns of GDH ratios observed. In vitro studies of phosphorylation and dephosphorylation have also been carried out, and the results suggest a possible correlation between cAMP, the GDH ratio, and cell form in B. poitrasii.
摘要
研究了不同含腺嘌呤化合物对本杰明氏菌酵母-菌丝体转变过程中NADP⁻/NAD-谷氨酸脱氢酶（GDH）比率的影响。在体内条件下，浓度为5.0 mM时，环磷酸腺苷（cAMP）和二丁酰cAMP分别使细胞保持酵母形态长达7小时和5小时，这反映在观察到的GDH比率模式中。还进行了磷酸化和去磷酸化的体外研究，结果表明cAMP、GDH比率和本杰明氏菌细胞形态之间可能存在相关性。
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