Ritchie A J, Whiteside M, Tolan M, McGuigan J A
Northern Ireland Regional Thoracic Surgical Department, Royal Victoria Hospital, Belfast, UK.
Eur J Cardiothorac Surg. 1993;7(8):420-2. doi: 10.1016/1010-7940(93)90006-w.
A prospective controlled randomized clinical study of 50 patients undergoing total thoracic oesophagectomy by one surgical team is described, in which one group of patients was given prophylactic digoxin and the other was not. The incidence of cardiac dysrhythmia in each group was compared. Fourteen (56%) of 25 patients digitalized, compared to 16 (64%) of 25 patients not digitalized, suffered cardiac dysrhythmia, with a total incidence of 30 patients (60%). The first onset of dysrhythmia occurred within 48 h in 89% of the patients who suffered this complication. These results indicate a high incidence of cardiac dysrhythmia in patients undergoing this operative procedure, which is not significantly reduced by prophylactic digitalization and which is likely to occur within 2 days of surgery.
本文描述了一个前瞻性对照随机临床研究，该研究纳入了由同一手术团队进行全胸段食管切除术的50例患者，其中一组患者给予预防性地高辛治疗，另一组未给予。比较了每组患者心律失常的发生率。在25例接受洋地黄化的患者中，有14例（56%）发生心律失常，而在25例未接受洋地黄化的患者中，有16例（64%）发生心律失常，总发生率为30例（60%）。89%发生该并发症的患者心律失常首次发作发生在48小时内。这些结果表明，接受该手术的患者心律失常发生率很高，预防性洋地黄化并不能显著降低其发生率，且心律失常很可能在术后2天内发生。
