Wallace L M, Priestman S G, Dunn J A, Priestman T J
South Birmingham District Psychology Service, Queen Elizabeth Hospital, UK.
Clin Oncol (R Coll Radiol). 1993;5(4):228-33. doi: 10.1016/s0936-6555(05)80234-1.
A cohort of 63 patients participating in a prospectively randomized trial evaluating two different radiotherapy regimens and adjuvant tamoxifen in the conservative management of early breast cancer were monitored by a series of psychological measures. The aim was to determine whether there was any difference between the radiotherapy schedules in terms of their impact on the patient's quality of life and whether measures of coping style and trait anxiety could be used to predict the subjective response to treatment. Overall, radiotherapy had little effect on quality of life and the differences between the two regimens were minor with significantly more of those women on the longer treatment schedule experiencing a transient weight change, disruption of private life and loss of positivity compared with those on the shorter schedule. In anticipating psychological adjustment to treatment, coping style proved unhelpful but trait anxiety was found to be a robust indicator of response, suggesting that it may be possible to determine in advance those patients who are likely to exhibit psychological distress during radiotherapy.
一组63名参与前瞻性随机试验的患者，该试验评估了两种不同放疗方案及辅助他莫昔芬在早期乳腺癌保守治疗中的效果，并通过一系列心理测量方法对他们进行监测。目的是确定放疗方案在对患者生活质量的影响方面是否存在差异，以及应对方式和特质焦虑的测量是否可用于预测对治疗的主观反应。总体而言，放疗对生活质量影响不大，两种方案之间的差异较小，与接受较短疗程的女性相比，接受较长疗程治疗的女性中，有更多人经历了短暂的体重变化、私生活受到干扰以及积极性丧失。在预期对治疗的心理适应方面，应对方式被证明并无帮助，但特质焦虑被发现是反应的有力指标，这表明有可能提前确定那些在放疗期间可能出现心理困扰的患者。
