Farningham D A, Whyte C C
Rowett Research Institute, Bucksburn, Aberdeen.
Br J Nutr. 1993 Jul;70(1):37-46. doi: 10.1079/bjn19930103.
Sheep fed ad lib. on a good-quality pelleted diet (g/kg; hay 500, barley 300, molasses, fish meal and minerals) were infused via the hepatic portal vein with mixtures of the sodium salts of volatile fatty acids, acetate and propionate, and a variety of equivalent osmotic loads. Propionate infused at rates between 0.6 and 2.5 mmol/min consistently reduced food intake in a linear, dose-related manner. Propionate infusions resulted in consistent dose-related increases in peripheral venous plasma glucose concentration but variable changes in insulin concentration. Infusion of osmotically balanced mixtures of propionate, acetate, mannitol or saline (9 g NaCl/l) indicated that at constant osmotic loading propionate caused a greater reduction in intake than other infusions. Acetate infusions only depressed food intake when administered as a 1 M solution. Lower concentrations had little effect, similar to that of equivalent osmotic loads of mannitol or saline. It is concluded that portal propionate flow has a potential role in the control of food intake in ruminants which is independent of osmotic effects or changes in plasma insulin concentration.
给自由采食优质颗粒饲料（克/千克；干草500、大麦300、糖蜜、鱼粉和矿物质）的绵羊经肝门静脉输注挥发性脂肪酸钠盐（乙酸盐和丙酸盐）混合物以及各种等渗负荷物。以0.6至2.5毫摩尔/分钟的速率输注丙酸盐持续以线性、剂量相关的方式减少采食量。输注丙酸盐导致外周静脉血浆葡萄糖浓度持续呈剂量相关增加，但胰岛素浓度变化不定。输注丙酸盐、乙酸盐、甘露醇或生理盐水（9克氯化钠/升）的等渗平衡混合物表明，在恒定渗透压负荷下，丙酸盐比其他输注物导致的采食量减少幅度更大。仅当以1摩尔/升溶液形式给药时，输注乙酸盐才会抑制采食量。较低浓度几乎没有影响，类似于甘露醇或生理盐水的等渗负荷物的影响。得出的结论是，门静脉丙酸盐流量在反刍动物采食量控制中具有潜在作用，这与渗透效应或血浆胰岛素浓度变化无关。
