Burger D M, Meenhorst P L, Beijnen J H
Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.
Pharm World Sci. 1995 Mar 24;17(2):25-30. doi: 10.1007/BF01875051.
In this paper aspects of the clinical pharmacokinetics of the antiretroviral agents zidovudine, didanosine and zalcitabine are reviewed. Special attention is paid to possibly altered pharmacokinetics in special circumstances, such as hepatic and renal dysfunction, pregnancy, stage of disease, etc. The dideoxynucleoside antiretroviral agents have some clinical pharmacokinetic properties in common (rapid absorption and elimination), but substantial differences exist in their degree of absorption, metabolism and penetration into the cerebrospinal fluid. All agents display wide interpatient variability in pharmacokinetic parameters. The relevance of therapeutic drug monitoring of antiretroviral agents is also discussed.
本文综述了抗逆转录病毒药物齐多夫定、去羟肌苷和扎西他滨的临床药代动力学方面。特别关注特殊情况下（如肝肾功能不全、妊娠、疾病阶段等）可能改变的药代动力学。双脱氧核苷类抗逆转录病毒药物具有一些共同的临床药代动力学特性（吸收和消除迅速），但在吸收程度、代谢及脑脊液渗透方面存在显著差异。所有药物的药代动力学参数在患者间均表现出很大的变异性。本文还讨论了抗逆转录病毒药物治疗药物监测的相关性。
