一项关于血浆丝氨酸和甘氨酸浓度的家族性/遗传学研究。

A familial/genetic study of plasma serine and glycine concentrations.

作者信息

Devor E J, Waziri R

机构信息

Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.

出版信息

Biol Psychiatry. 1993 Aug 15;34(4):221-5. doi: 10.1016/0006-3223(93)90075-o.

DOI:10.1016/0006-3223(93)90075-o

PMID:8399818

Abstract

Plasma serine and glycine concentrations were assayed in a sample of 28 nuclear families (n = 108). Complex segregation analysis of these familial data reveals significant genetic control of concentrations via a single major gene locus. The serine and glycine metabolizing enzyme serine hydroxymethyltransferase (SHMT) is suggested as the most likely candidate for this single major gene locus.

摘要

在一个包含28个核心家庭（n = 108）的样本中检测了血浆丝氨酸和甘氨酸浓度。对这些家族数据进行的复杂分离分析显示，通过一个单一的主要基因座对浓度有显著的遗传控制。丝氨酸和甘氨酸代谢酶丝氨酸羟甲基转移酶（SHMT）被认为是这个单一主要基因座最有可能的候选基因。