Wilcox J, Waziri R, Sherman A, Mott J
Biol Psychiatry. 1985 Jan;20(1):41-9. doi: 10.1016/0006-3223(85)90133-7.
Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large bolus of L-serine (4 mM/kg) at breakfast and blood was drawn before breakfast, 2 hr, 4 hr, and 6 hr after serine ingestion. Baseline serine and SHMT activity differentiated between psychotics and nonpsychotics with high degrees of significance (p less than 0.0001) and p less than 0.01, respectively). Plasma serine levels 2 hr after serine ingestion were significantly higher (p less than 0.01) in nonpsychotics as compared with psychotics. Elimination of serine in psychotics was bimodal and was significantly different from that of nonpsychotics (p less than 0.0079, Moses test). These findings provide additional evidence for abnormal serine metabolism in psychotic patients.
我们之前的研究表明，与非精神病患者相比，精神病患者血浆丝氨酸水平异常升高，而血浆丝氨酸羟甲基转移酶（将丝氨酸裂解为甘氨酸）的活性异常降低。在本研究中，精神病患者和非精神病患者在早餐时摄入大剂量的L-丝氨酸（4 mM/kg），并在早餐前、摄入丝氨酸后2小时、4小时和6小时采集血液。基线丝氨酸和丝氨酸羟甲基转移酶活性在精神病患者和非精神病患者之间分别具有高度显著性差异（p小于0.0001）和p小于0.01）。与精神病患者相比，非精神病患者在摄入丝氨酸后2小时的血浆丝氨酸水平显著更高（p小于0.01）。精神病患者中丝氨酸的消除呈双峰模式，且与非精神病患者的消除模式有显著差异（p小于0.0079，摩西检验）。这些发现为精神病患者丝氨酸代谢异常提供了额外证据。
