Waziri R, Wilcox J, Sherman A D, Mott J
Psychiatry Res. 1984 Jun;12(2):121-36. doi: 10.1016/0165-1781(84)90012-x.
Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics and controls. PSL differentiated psychotics from nonpsychotics with a high (95%) degree of confidence. PSL were highly correlated to SHMT activity, suggesting that the hyperserinemia in psychotics was due to the abnormality of the enzyme. Previously psychotic patients who had been treated and were psychosis free still manifested abnormal high PSL and abnormal enzyme activity. These findings suggest that disturbed serine metabolism may be a biological marker and a vulnerability factor for psychosis.
一组被诊断为重度或非典型精神病的患者的血浆丝氨酸水平（PSL）显著高于非精神病诊断患者或非患者对照组。将丝氨酸代谢为甘氨酸的丝氨酸羟甲基转移酶（SHMT）在精神病患者中与非精神病患者和对照组相比显示出异常活性。PSL以高（95%）置信度区分精神病患者和非精神病患者。PSL与SHMT活性高度相关，表明精神病患者的高丝氨酸血症是由于该酶的异常所致。之前接受过治疗且已无精神病症状的精神病患者仍表现出异常高的PSL和异常的酶活性。这些发现表明，丝氨酸代谢紊乱可能是精神病的一种生物学标志物和易患因素。
