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一种用于关联肽性质的公式及其在预测蛋白质中人类免疫缺陷病毒蛋白酶可切割位点的应用。

A formulation for correlating properties of peptides and its application to predicting human immunodeficiency virus protease-cleavable sites in proteins.

作者信息

Chou J J

机构信息

Department of Physics, University of Michigan, Ann Arbor 48104.

出版信息

Biopolymers. 1993 Sep;33(9):1405-14. doi: 10.1002/bip.360330910.

DOI:10.1002/bip.360330910
PMID:8400033
Abstract

A mathematical frame has been established to generally formulate the correlating properties of peptides. The formulation can be used to study the specificity of multisite enzymes, particularly in predicting the susceptible sites in proteins by human immunodeficiency virus (HIV) proteases, and hence can serve as a supplementary means in designing HIV protease inhibitors as potential drugs against acquired immunodeficiency syndrome.

摘要

已经建立了一个数学框架来总体阐述肽的相关特性。该公式可用于研究多位点酶的特异性，特别是在预测人类免疫缺陷病毒（HIV）蛋白酶作用于蛋白质的敏感位点方面，因此可作为设计HIV蛋白酶抑制剂（作为抗获得性免疫缺陷综合征潜在药物）的一种辅助手段。

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