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[经心腔电刺激对实验性心肌梗死梗死周边区微循环床功能的影响]

[The effect of transcardiac galvanization on the function of the microcirculatory bed of the peri-infarct area in experimental myocardial infarct].

作者信息

Maslov A G, Smirnov V P

出版信息

Biull Eksp Biol Med. 1993 Jul;116(7):85-6.

PMID:8400196
Abstract

The model of experimental myocardial infarction in rats was used to study the effect of procedures of transcardiac galvanization (the current power 4 mA, duration 60 min) on the condition of the peri-infarction zone microcirculatory bed. The morphometric studies of the microcirculatory bed were performed using PAS reaction with amylase using a net with equidistant points. Two runs of transcardiac galvanization by the end of the first 24 hours of myocardial infarction was shown to improve the condition of the capillary network, to increase the relative and absolute area of the capillaries, the number of opened reserve capillaries, to reduce the distance of oxygen and metabolites diffusion from capillaries to cardiomyocytes in the peri-infarction zone thereby creating favourable conditions for the remaining viable myocardium and for stabilization of the affected zone.

摘要

采用大鼠实验性心肌梗死模型,研究经心内通直流电(电流强度4毫安,持续时间60分钟)对梗死周边区微循环床状况的影响。使用等距点网格,通过淀粉酶过碘酸希夫反应(PAS反应)对微循环床进行形态计量学研究。结果显示,在心肌梗死的最初24小时结束时进行两次经心内通直流电操作,可改善毛细血管网状况,增加毛细血管的相对和绝对面积、开放储备毛细血管的数量,缩短梗死周边区从毛细血管到心肌细胞的氧气和代谢产物扩散距离,从而为剩余存活心肌以及受影响区域的稳定创造有利条件。

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